 | | Vol. 13.07 – 22 February, 2022 |
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| Researchers found that megakaryocyte/platelet-specific lactate dehydrogenase A (LdhA)-knockout mice showed an increased number of platelets with remarkably accelerated megakaryocyte maturation and proplatelet formation.
[Blood] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists reported that multiple myeloma, an incurable hematological malignancy, could be specifically targeted by a monoclonal antibody that recognized a ubiquitously present protein, CD98 heavy chain.
[Science Translational Medicine] |
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| Investigators revealed that CCRL2 was up-regulated in primitive cells from patients with myelodysplastic syndrome and secondary AML.
[Science Advances] |
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| To interrogate the effect of protein expression alterations in AML, researchers performed a quantitative mass spectrometry in parallel with RNAseq analysis using AML mouse models.
[Leukemia] |
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| Secondary transplantation from PDX and ΔPTEN models of T-cell acute lymphoblastic leukemia (T-ALL), confirmed delayed leukemia development and extended survival of mice engrafted with T-ALL from ARV-825 treated mice, providing functional confirmation of depletion of leukemia-initiating cells.
[Leukemia] |
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| The combination of reovirus and NAD+ depletion achieved greater antitumor effects in KMS12 tumors in vivo and patient-derived CD138+ multiple myeloma cells.
[Molecular Therapy Oncolytics] |
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| The authors hypothesized that the inflammatory environment of Group A Streptococcus infection drove rapid hematopoietic stem and progenitor cell (HSPC) differentiation and depletion that could be rescued by infusion of donor HSPCs.
[eLife] |
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| Investigators performed an in-depth glycosphingolipid (GSL) glycan analysis of 19 AML cell lines using porous graphitized carbon liquid chromatography-mass spectrometry revealing strikingly different GSL glycan profiles between the various AML cell lines.
[Journal of Proteome Research] |
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| In a co-culture system of human umbilical vein endothelial cells and acute lymphoblastic leukemia (ALL) cells, serine protease inhibitor Kazal type 1 (SPINK1) exposure resulted in enhanced endothelial cell motility and ALL cells trans-endothelial migration.
[Scientific Reports] |
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| Researchers conducted a randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of hydroxyurea in transfusion-dependent β-thalassaemia.
[Scientific Reports] |
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| Scientists discuss available FDA-approved anti-leukemia drugs and therapies with a focus on the advances in the development of anti-leukemia drug delivery systems.
[Chemical Society Reviews] |
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| The authors discuss how aberrant expression of C-X-C motif chemokine 12 (CXCL12)/C-X-C chemokine receptor type 4 (CXCR4) and CXCL12/CXCR7 pathways might regulate leukemogenesis and end by outlining the key news of preclinical and clinical investigations in leukemia treatment.
[European Journal of Pharmacology] |
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| BeiGene announced that the US FDA has accepted a supplemental new drug application or BRUKINSA® for the treatment of adult patients with chronic lymphocytic leukemia or small lymphocytic lymphoma.
[BeiGene] |
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| Texas Tech University Health Sciences Center (TTUHSC) El Paso has received more than a quarter-million dollars to study the proteins that contribute to disease progression and drug resistance in AML and chronic myeloid leukemia.
[El Paso Herald-Post] |
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| April 3 – April 5
Lisbon, Portugal |
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| | BC Cancer Research Institute – Vancouver, British Columbia, Canada |
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| TU Dresden – Dresden, Germany |
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| | George Mason University – Prince William, Virginia, United States |
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| | Stanford University – Stanford, California, United States |
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| | Penn State College of Medicine – Hershey, Pennsylvania, United States |
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