 | | Vol. 13.12 – 29 March, 2022 |
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| To identify the signals responsible for HSC formation, scientists used single cell RNA-sequencing to simultaneously analyze the transcriptional profiles of aorta-gonad-mesonephros region-derived cells transitioning from hemogenic endothelium to HSCs,
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators profiled the transcriptomes of 16 murine hematopoietic cell populations by deep RNA sequencing and identified a novel lncRNA, Gm15915, that was highly expressed in erythroid-related progenitors and erythrocytes.
[Journal of Experimental Medicine] |
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| Genetic fate-mapping analysis revealed that liver Ly49E+ ILC1s with strong cytotoxicity originated from embryonic non–bone marrow hematopoietic progenitor cells, persisted locally during postnatal life, and mediated protective immunity against cytomegalovirus infection in newborn mice.
[Journal of Experimental Medicine] |
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| Scientists found that pharmacological inhibition of NF-κB pathway in both control and CoCl2-treated mesenchymal stromal cells completely blocked their intercellular communication with the co-cultured HSCs and progenitor cells, resulting in an extremely poor output of hematopoietic cells.
[Stem Cell Reviews and Reports] |
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| Investigators proposed a mechanism by which hydroquinone induced the malignant progression of chronic myeloid leukemia cells.
[Biochemical Pharmacology] |
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| Nox4 inactivation in normal HSCs and progenitor cells caused a minor reduction in HSC numbers and reconstitution capacity.
[Journal of Cancer Research and Clinical Oncology] |
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| The authors found that lipid transport-associated genes were upregulated in the high interleukin-6 (IL-6) receptor expression group. IL-6 promoted fatty acid uptake in both AML cell lines and primary AML cells.
[Experimental Cell Research] |
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| Researchers observed the adverse effects of pentachlorophenol (PCP) on the development of zebrafish by using fluorescence microscopy, and saw that increased concentrations of PCP decreased the numbers of normal red blood cells and myeloid cells.
[PLoS One] |
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| The combination of crenolanib and sorafenib was tolerable with antileukemic activities and rare emergence of FLT3-TKD mutations, which warrants further investigation.
[Clinical Cancer Research] |
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| In successive UK clinical trials for pediatric acute lymphoblastic leukemia (ALL), polyethylene glycol-conjugated E. coli L-asparaginase 1000 iu/m2 was administered intramuscularly with risk-stratified treatment.
[British Journal of Haematology] |
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| Investigators review the most recent advances in understanding the molecular basis of clonal hematopoiesis in health and disease.
[Trends in Molecular Medicine] |
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| The authors focus on induction therapies prior to ASCT examining the latest data and guidelines on triplet and quadruplet regimens.
[Blood Cancer Journal] |
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| Scientists examine the immunosuppressive features of the leukemia microenvironment and explore publications that have employed syngeneic modeling in adoptive cell therapy studies for the improvement of therapy for leukemias.
[Frontiers in Immunology] |
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| Akron BioProducts and Vor Bio announced an agreement to develop and manufacture cGMP nucleases. The companies will collaborate in the development and manufacture of starting materials needed to advance potentially transformative treatments for blood cancers into the clinic.
[Akron BioProducts] |
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| Legend Biotech Corporation announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency recommended Janssen Pharmaceutica NV’s marketing authorization of CARVYKTI® for the treatment of adults with relapsed and refractory multiple myeloma.
[Legend Biotech Corporation] |
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| May 5 – 8, 2022
Boston, Massachusetts, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | University Children’s Hospital of Zurich – Zurich, Switzerland |
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| University of Illinois Chicago – Chicago, Illinois, United States |
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| | The University of California, Davis – Davis, California, United States |
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| | TU Dresden – Dresden, Germany |
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Cancer Stem Cell News
Cell Therapy News
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Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
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