Hematopoiesis News Volume 13.14 | Apr 12 2022

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    2022-04-12 | HN 13.14


    Hematopoiesis News by STEMCELL Technologies
    Vol. 13.14 – 12 April, 2022
    TOP STORY

    CellComm Infers Cellular Crosstalk That Drives Hematopoietic Stem and Progenitor Cell Development

    Researchers developed and applied CellComm to investigate how the aorta–gonad–mesonephros microenvironment dictated hematopoietic stem and progenitor cell emergence.
    [Nature Cell Biology]

    Abstract

    Explore virtual support and resources to stay productive and connected with your field.
    PUBLICATIONSRanked by the impact factor of the journal

    Lipase-Triggered Drug Release from BCL2 Inhibitor ABT-199-Loaded Nanoparticles to Elevate Anti-Leukemic Activity through Enhanced Drug Targeting on the Mitochondrial Membrane

    Scientists compared the anti-leukemic ability of pure ABT-199 and PEG-ABT-199 in vitro and in vivo.
    [Acta Biomaterialia]

    AbstractGraphical Abstract

    Acute Lymphoblastic Leukemia-Derived Extracellular Vesicles Affect Quiescence of Hematopoietic Stem and Progenitor Cells

    Investigators discovered that hematopoietic stem and progenitor cells were mainly targeted by acute lymphoblastic leukemia extracellular vesicles, affecting their quiescence and maintenance in the murine bone marrow environment.
    [Cell Death & Disease]

    Full Article

    Assessment of Safety and Immunogenicity of MHC Homozygous iPSC-Derived CD34+ Hematopoietic Progenitors in a NHP Model

    The authors demonstrated that infusing hematopoietic progenitors derived from major histocompatibility complex (MHC) homozygous induced pluripotent stem cells (iPSC) (iHPs) were well-tolerated and safe, observing no teratomas or tumors in the Mauritian cynomolgus macaque up to one year after HSC transplant and iHP infusion.
    [Blood Advances]

    Abstract

    Targeting Matrix Metallopeptidase 2 by Hydroxyurea Selectively Kills Acute Myeloid Mixed-Lineage Leukemia

    Researchers showed that hydroxyurea could kill mixed-lineage leukemia-rearranged AML cells through the necroptosis process.
    [Cell Death Discovery]

    Full Article

    Human Placental Hematopoietic Stem Cell Derived Natural Killer Cells (CYNK-001) Mediate Protection against Influenza A Viral Infection

    Scientists investigated the effects of CYNK-001, human placental hematopoietic stem cell derived NK cells that exhibited strong cytolytic activity against a range of malignant cells and expressed high levels of activating receptors, against influenza A virus infections.
    [Human Vaccines & Immunotherapeutics]

    Full Article

    Isthmin 1 Is Expressed by Progenitor-Like Cells in the Lung: Phenotypical Analysis of Isthmin 1+ Hematopoietic Stem-Like Cells in Homeostasis and during Infection

    Using multiparametric flow cytometry, scientists identified mesenchymal, endothelial, and hematopoietic progenitor cells that express the secreted small protein Isthmin 1.
    [Journal of Immunology Research]

    Full Article

    Growth and Nutritional Outcomes in Children Post-Hematopoietic Stem Cell Transplant without Exposure to Total Body Irradiation

    Scientists assessed the change in height standard deviation score and the final adult height in children who underwent chemotherapy-only conditioned hematopoietic stem cell transplant and to identify predictors of poor growth.
    [Clinical Oncology]

    Abstract

    Cryopreservation of Rare Pediatric Red Blood Cells for Support Following Bone Marrow Transplant

    A protocol was developed for the collection of small volume pediatric whole blood via peripheral venipuncture with collection into 10 ml syringes containing anticoagulants.
    [Transfusion]

    Abstract

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    REVIEWS

    Efficacy and Safety of Allogeneic Hematopoietic Stem Cell Transplant in Adults with Hemophagocytic Lymphohistiocytosis: A Systematic Review of Literature

    Scientists analyze available literature on the role of allogeneic hematopoietic stem cell transplant in adolescent and adult patients using PubMed, Cochrane, Embase and ClinicalTrials.gov.
    [Bone Marrow Transplantation]

    Abstract

    INDUSTRY AND POLICY NEWS

    SELLAS Life Sciences’ Newly Licensed GFH009 Asset Shows Significant Anti-Leukemic Effect in Acute Myeloid Leukemia Patients Relapsed/Refractory to Venetoclax in Ongoing Phase I Study

    SELLAS Life Sciences Group, Inc. announced that the first AML patient has enrolled in the fifth dose level cohort, out of the expected six dose cohorts, in the ongoing Phase I dose-escalating clinical trial with SELLAS’ newly in-licensed GFH009 asset.
    [SELLAS Life Sciences Group, Inc.]

    Press Release

    FEATURED EVENT

    ASGCT 25th Annual Meeting

    May 16 – 19, 2022
    WASHINGTON, D.C., United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – AI in Health Diagnosis

    Institute of AI for Health, Helmholtz – Neuherberg, Germany

    Postdoctoral Research Associate – Pharmaceutical Sciences

    St. Jude Children’s Research Hospital – Memphis, Texas, United States

    Postdoctoral Scholarship – Molecular Biology

    University of Gothenburg – Gothenburg, Sweden

    Postdoctoral Researcher – Leukemia Subtypes

    University Children’s Hospital of Zurich – Zurich, Switzerland

    Postdoctoral Research Associate – Oncology

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    > See All Jobs

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