 | | Vol. 13.18 – 10 May, 2022 |
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| Researchers explored transcriptomes of hematopoietic stem and progenitor cells with Shp2 mutations derived from juvenile myelomonocytic leukemia patients and a novel Noonan syndrome zebrafish model.
[eLife] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors demonstrated that elevated MEF2C expression blocks NOTCH-induced T cell differentiation while promoting a B-lineage program.
[JCI Insight] |
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| Researchers studied the mechanisms involved in homing and engraftment of Intra-bone marrow transplanted and intravenous. transplanted genetically modified human hematopoietic stem and progenitor cells.
[JCI Insight] |
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| The authors investigated the role of the reprogramming factor KLF4 in acute myeloid leukemia because of its critical role in the self-renewal and stemness of embryonic and cancer stem cells.
[Stem Cells] |
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| Scientists showed that ΔA146Ply, a mutant of pneumolysin that lacked hemolytic activity, inhibited autophagy of triple-negative breast cancer cells by activating mannose receptor and toll-like receptor 4 and that tumor-bearing mice tolerated ΔA146Ply well.
[Experimental and Molecular Medicine] |
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| Researchers reported the 5-hydroxymethylcytosine (5hmC) landscape of normal hematopoiesis and identified cell type-specific 5hmC profiles associated with active transcription and chromatin accessibility of key hematopoietic regulators.
[Blood Cancer Discovery] |
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| To investigate their role in AML, mismatch of KIR2DL1, KIR3DL1, and KIR3DL2-ligand were retrospectively assessed in patients undergoing cord blood transplantation with graft-versus-host disease prophylaxis comprising a calcineurin inhibitor plus methotrexate or mycophenolate mofetil.
[Bone Marrow Transplantation] |
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| Researchers demonstrated that a short treatment of mobilized peripheral blood cells with Fas ligand for two hours using a closed automated cell processing system selectively induced apoptosis of specific donor T cells, B cells and antigen-presenting cells.
[Bone Marrow Transplantation] |
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| Researchers compared the outcomes of autologous stem cell transplantation with those of allogeneic stem cell transplantation from a human leukocyte antigen-matched related donor in patients with Philadelphia chromosome-negative B-lineage acute lymphoblastic leukemia.
[International Journal of Hematology] |
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| A prospective observational study was conducted in 36 adult patients undergoing allogeneic hematopoietic stem cell transplantation.
[International Journal of Hematology] |
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| Researchers evaluated the efficacy of azacitidine in preventing relapse after HSC transplantation in patients with myeloid malignancies.
[Expert Review of Hematology] |
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| Moleculin Biotech, Inc. announced that it has received approval from the United Kingdom’s MHRA to proceed with a first-in-human Phase Ia study to evaluate the safety and pharmacokinetics of WP1122 in healthy volunteers for the treatment of COVID-19.
[Moleculin Biotech, Inc.] |
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| June 15 – 18, 2022
San Francisco, California, United States |
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| Flanders Institute for Biotechnology – Leuven, Belgium |
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| | NHS Blood and Transplant – London, England, United Kingdom |
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| University Children’s Hospital – Zurich, Switzerland |
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| | University Children’s Hospital – Zurich, Switzerland |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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