 | | Vol. 13.20 – 24 May, 2022 |
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| Researchers identified oxidative phosphorylation as a critical pathway for leukemia cell survival and demonstrate a direct relationship between NOTCH1, elevated OxPhos gene expression, and acquired chemoresistance in pre-leukemic and leukemic models.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| To investigate the physiological significance of p27 tyrosine phosphorylation, scientists generated a knock-in mouse model where Y88 was replaced by phenylalanine.
[Leukemia] |
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| The authors identified LIN28B known for its role in promoting fetal-like self-renewal, as an insulator against the establishment of a megakaryocyte-biased hematopoietic stem cell pool.
[Blood Advances] |
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| Scientists found that the CDH23 expression was aberrantly upregulated in patients with acute myeloid leukemia and could be used as an independent risk factor of overall survival using Cox multivariate analysis.
[BMC Cancer] |
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| Researchers demonstrated that genetic loss of 15-PGDH (Hpgd) confers a protective effect on the aging of murine hematopoietic and gastrointestinal tissues.
[PLoS One] |
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| Scientists performed whole-genome bisulfite sequencing across ALL subtypes, leukemia cell lines and healthy hematopoietic cells, and showed that, unlike most cancers, ALL samples exhibited CpG island hypermethylation but the minimal global loss of methylation.
[Nature Cancer] |
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| Using blood samples from patients who underwent allogeneic hematopoietic stem cell transplantation under regimens containing post-transplant cyclophosphamide (PTCy) versus those who received no PTCy, researchers examined the impact of PTCy on the post-transplant immune response.
[Journal of Hematology & Oncology] |
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| To verify the safety and potential effect on ALS progression of a low-intensity immunosuppressive regimen followed by autologous hematopoietic stem cell transplantation in amyotrophic lateral sclerosis patients.
[Journal of Neurology] |
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| Researchers evaluated whether alveolar nitric oxide concentration levels could reflect the presence of Organizing pneumonia and structural airway changes in patients after allo-hematopoietic stem cell transplantation.
[Annals of Hematology] |
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| Scientists determined the incidence of kidney complications in pediatric allogeneic hematopoietic stem cell transplantation patients.
[Pediatric Nephrology] |
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| The authors discuss current concepts of antibody-based therapies and results from emerging antibody-based therapeutics for the treatment of acute myeloid leukemia.
[Cancer Treatment Reviews] |
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| Foghorn Therapeutics Inc. announced the FDA has placed the Phase I dose-escalation study of FHD-286 in relapsed and/or refractory acute myelogenous leukemia and myelodysplastic syndrome on partial clinical hold.
[Foghorn Therapeutics, Inc. (BioSpace, Inc.)] |
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| May 30 – June 1, 2022
Brisbane, Queensland, Australia |
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| City of Hope – Monrovia, California, United States |
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| Duke University – Durham, North Carolina, United States |
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| Flanders Institute for Biotechnology – Leuven, Belgium |
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| | NHS Blood and Transplant – London, England, United Kingdom |
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| University Children’s Hospital – Zurich, Germany |
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