 | | Vol. 13.21 – 31 May, 2022 |
| |
|
|
| The authors showed that mobilizers created an opportunity for seamless engraftment of exogenous cells, which effectively outcompeted those mobilized, to repopulate the depleted bone marrow.
[Cell] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Scientists delineated the activity of transcription factor myocyte enhancer factor-2 family members, which were found to be enriched at the 3’LTR and play an important role in the pathogenesis of adult T cell leukemia and lymphoma.
[Haematologica] |
|
|
|
| To understand how disease heterogeneity links with therapy response, researchers determined the leukemia cell hierarchy makeup from bulk transcriptomes of more than 1,000 patients through deconvolution using single-cell reference profiles of leukemia stem, progenitor and mature cell types.
[Nature Medicine] |
|
|
|
| Investigators identified via a CRISPR–Cas9 genetic screen two members of the NFI transcription factor family — NFIA and NFIX — as HBG1/2 repressors.
[Nature Genetics] |
|
|
|
| Sodium/hydrogen exchanger (NHE1)-mediated intracellular alkalization played a key pathogenetic role in transmitting the proliferative signal from mutated-kinase and could be exploited for therapeutic intervention in AML.
[Leukemia] |
|
|
|
| To investigate the role of schlafen2 (Slfn2) in the regulation of HSCs, scientists studied HSC function in the elektra mouse model, where the elektra allele of the Slfn2 gene contained a point mutation causing loss of function of the Slfn2 protein.
[Haematologica] |
|
|
|
| Scientists used multi-omics approaches together with functional assays to assess global DNA methylome dynamics during the endothelial cells-to-hematopoietic stem and progenitor cells transition in zebrafish, and determined that DNA methyltransferase 1 was essential for HSPC generation via repression of Notch signaling.
[Development] |
|
|
|
| CD34+ hematopoietic stem cells were isolated from human umbilical cord blood and differentiated toward erythrocyte lineage for 14 days in various concentrations of indoxyl sulfate (IS). The effects of IS on cell proliferation, differentiation, apoptosis, and senescence were determined.
[Experimental Biology and Medicine] |
| |
|
|
| Researchers found, for the first time, that C-reactive-protein/albumin ratio at diagnosis predicted the prognosis of elderly patients with newly diagnosed AML treated without hematopoietic stem cell transplantation.
[Scientific Reports] |
|
|
|
|
| The authors focus on the abnormal pathological hematopoietic differentiation in cancer induced by tumor-released granulocyte colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF).
[Febs Open Bio] |
|
|
|
|
| Novartis announced the FDA has granted accelerated approval for Kymriah® for the treatment of adult patients with relapsed or refractory follicular lymphoma after two or more lines of systemic therapy.
[Novartis] |
|
|
|
|
| September 19 – 20, 2022
Vejle, Denmark |
|
|
|
|
|
| | Columbia University – New York, New York, United States |
|
|
|
| | Van Andel Institute – Grand Rapids, Michigan, United States |
|
|
|
| | Francis Crick Institute – London, England, United Kingdom |
|
|
|
| | City of Hope – Monrovia, California, United States |
|
|
|
| | Albert Einstein College of Medicine – New York, New York, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
