Hematopoiesis News Volume 13.28 | July 19 2022

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    2022-07-19 | HN 13.28


    Hematopoiesis News by STEMCELL Technologies
    Vol. 13.28 – 19 July, 2022
    TOP STORY

    Inflammatory Exposure Drives Long-Lived Impairment of Hematopoietic Stem Cell Self-Renewal Activity and Accelerated Aging

    HSCs from challenged mice demonstrated multiple cellular and molecular features of accelerated aging and developed clinically relevant blood and bone marrow phenotypes not normally observed in aged laboratory mice but commonly seen in elderly humans.
    [Cell Stem Cell]

    AbstractGraphical Abstract

    Dr. Jackie Damen discusses why the CFU assay should be a vital part of your cell therapy workflow in this on-demand webinar.
    PUBLICATIONSRanked by the impact factor of the journal

    Grab Regulates Transferrin Receptor Recycling and Iron Uptake in Developing Erythroblasts

    Scientists identified the guanine nucleotide exchange factor Grab as a critical regulator of the transferrin cycle and iron metabolism during erythropoiesis.
    [Blood]

    Abstract

    Combined Single-Cell Tracking and Omics Improves Blood Stem Cell Fate Regulator Identification

    Using asymmetrically dividing blood stem cells, researchers developed a pipeline for imaging, tracking, isolating and transcriptome sequencing of single cells.
    [Blood]

    Abstract

    ID2 and HIF-1α Collaborate to Protect Quiescent Hematopoietic Stem Cells from Activation, Differentiation, and Exhaustion

    The authors reported that genetic ablation of Id2 in adult HSCs promoted increased HSC activation and differentiation, which resulted in HSC exhaustion and bone marrow failure over time.
    [Journal of Clinical Investigation]

    Full ArticleGraphical Abstract

    GFI1B Acts as a Metabolic Regulator in Hematopoiesis and Acute Myeloid Leukemia

    Investigators explored the role of Gfi1b in metabolism reprogramming during hematopoiesis and leukemogenesis.
    [Leukemia]

    Full Article

    Leukemia-Initiating HSCs in Chronic Lymphocytic Leukemia Reveal Clonal Leukemogenesis and Differential Drug Sensitivity

    Researchers demonstrated a microchannel electroporation microarray that injects RNA-detecting probes into single live cells, allowing the imaging and characterization of heterogeneous leukemia-initiating cells by intracellular RNA expression.
    [Cell Reports]

    Full ArticleGraphical Abstract

    PDGFRβ+ Cells Play a Dual Role as Hematopoietic Precursors and Niche Cells During Mouse Ontogeny

    Investigators showed that PDGFRβ is expressed in distinct perivascular stromal cell layers surrounding the mid-gestation dorsal aorta, and its deletion impairs hematopoiesis.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Single-Cell Transcriptome Analysis of Embryonic and Adult Endothelial Cells Allows to Rank the Hemogenic Potential of Post-Natal Endothelium

    The authors used single-cell transcriptomics analysis to compare embryonic and post-natal endothelial cells to investigate the potential of adult vasculature to be reprogrammed in HSCs.
    [Scientific Reports]

    Full Article

    Impact of Anti-T-Lymphocyte Globulin Dosing on GVHD and Immune Reconstitution in Matched Unrelated Myeloablative Peripheral Blood Stem Cell Transplantation

    Researchers compared graft versus host disease (GVHD) and immune reconstitution after myeloablative matched unrelated peripheral blood stem cell allogeneic stem cell transplant between 30 mg/Kg and 60 mg/Kg anti-lymphocyte globulin.
    [Bone Marrow Transplantation]

    Full Article

    Cell Preparation For Crossmatch Assays
    REVIEWS

    Targeting Stem Cells in Myelodysplastic Syndromes and Acute Myeloid Leukemia

    The selective persistence of rare leukemic stem cells following therapy-induced remission implies unique resistance mechanisms of leukemic stem cells towards conventional therapeutic strategies and that leukemic stem cells represent the cellular origin of relapse.
    [Journal of Internal Medicine]

    Full ArticleGraphical Abstract

    Development and Clinical Translation Considerations for the Next Wave of Gene Modified Hematopoietic Stem and Progenitor Cells Therapies

    Recent advances in genome modification technology coupled with the longstanding clinical success of hematopoietic stem and progenitor cells (HSPCs) warrants great optimism for the next generation of engineered HSPC-based therapies.
    [Expert Opinion On Biological Therapy]

    Abstract

    INDUSTRY AND POLICY NEWS

    Ascentage Pharma and Innovent Announce the China NMPA Accepted and Granted Priority Review Designation to a New Drug Application for Olverembatinib for the Treatment of Drug-Resistant CML

    Ascentage Pharma and Innovent Biologics, Inc. announced that the Center for Drug Evaluation of China National Medical Products Administration (NMPA) has accepted and granted Priority Review designation to a New Drug Application.
    [Ascentage Pharma (Cision US Inc.)]

    Press Release

    FEATURED EVENT

    3D Cell Culture Symposium

    1 December 2022
    Online

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellows – Stem Cell Biology

    Institute for Research in Biomedicine – Barcelona, Spain

    Associate Professor – Thematic Research Programs

    The Chinese University of Hong Kong – Hong Kong, China

    Associate Professor – Oncology

    Fred Hutchinson Cancer Research Center – Seattle, Washington, United States

    Scientific Editor – Blood Cancer Discovery

    American Association for Cancer Research – Various, United States

    Postdoctoral Fellow – Microenvironment and Signaling

    Albert Einstein College of Medicine – New York, New York, United States

    > See All Jobs

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