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mladbrook

Phenotypic Heterogeneity Driven by Plasticity of the Intermediate EMT State Governs Disease Progression and Metastasis in Breast Cancer

[Science Advances] Investigators isolated multiple distinct single-cell clones from the SUM149PT human breast cell line spanning the epithelial-to-mesenchymal transition spectrum having diverse migratory, tumor-initiating, and metastatic qualities, including three unique intermediates.

Triple-Negative Breast Cancer Metastasis Involves Complex Epithelial-Mesenchymal Transition Dynamics and Requires Vimentin

[Science Translational Medicine] The authors demonstrated that spontaneous triple-negative breast cancer tumors from a genetically engineered mouse model, multiple patient-derived xenografts, and archival patient samples exhibited large populations in vivo of hybrid E/M cells that lead invasion ex vivo while expressing both epithelial and mesenchymal characteristics.

CircPDSS1 Promotes the Proliferation, Invasion, Migration, and EMT of Breast Cancer Cell via Regulating miR-320c/CKAP5 Axis

[Cancer Cell International] CircPDSS1 was upregulated in BC cells, and circPDSS1 knockdown repressed BC cell malignant behaviors.

Detection and Spatiotemporal Analysis of In Vitro 3D Migratory Triple-Negative Breast Cancer Cells

[Annals of Biomedical Engineering] Scientists present an image processing and segmentation pipeline for the detection of 3D GFP-fluorescent triple-negative breast cancer cell nuclei, and they performed quantitative analysis of the formed spatial patterns and their temporal evolution.

Dysregulation of Splicing Variants and Spliceosome Components in Breast Cancer

[Endocrine-Related Cancer] Investigators compile the current knowledge demonstrating the altered expression of splicing variants and spliceosomal components in BCa, showing the existence of a growing body of evidence supporting the close implication of the alteration in the splicing process in mammary tumorigenesis.

Glucose Deprivation Reduces Proliferation and Motility, and Enhances the Anti-Proliferative Effects of Paclitaxel and Doxorubicin in Breast Cell Lines In Vitro

[PLoS One] Scientists examined the effect of glucose as well as its deprivation, and antagonism using the non-metabolized analogue 2-deoxy glucose, on the proliferation of several breast cancer cell lines MCF7, MDA-MB-231, YS1.2 and pII and one normal breast cell line, using the MTT assay.

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Lipoic Acid Functions in Paneth Cells to Prevent Human Intestinal Stem Cell Aging

[Nature Communications] Scientists discerned that the effect of α-lipoic acid on mitigating intestinal stem cell (ISC) aging is contingent upon the presence of Paneth cells.

MTCH2 Deficiency Promotes E2F4/TFRC-Mediated Ferroptosis and Sensitizes Colorectal Cancer Liver Metastasis to Sorafenib

[Advanced Science] Investigators revealed the mechanism of mitochondrial carrier homolog 2 (MTCH2) deficiency-induced ferroptosis to inhibit the progression of colorectal cancer.

EZH2 Loss Promotes Gastric Squamous Cell Carcinoma

[Nature Communications] Researchers performed genomics analyses of twenty gastric squamous cell carcinoma samples and found that epigenetic regulation genes are among the most frequently mutated genes, including enhancer of zeste homolog 2 (EZH2).