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mladbrook

Phenotypic Heterogeneity Driven by Plasticity of the Intermediate EMT State Governs Disease Progression and Metastasis in Breast Cancer

[Science Advances] Investigators isolated multiple distinct single-cell clones from the SUM149PT human breast cell line spanning the epithelial-to-mesenchymal transition spectrum having diverse migratory, tumor-initiating, and metastatic qualities, including three unique intermediates.

Triple-Negative Breast Cancer Metastasis Involves Complex Epithelial-Mesenchymal Transition Dynamics and Requires Vimentin

[Science Translational Medicine] The authors demonstrated that spontaneous triple-negative breast cancer tumors from a genetically engineered mouse model, multiple patient-derived xenografts, and archival patient samples exhibited large populations in vivo of hybrid E/M cells that lead invasion ex vivo while expressing both epithelial and mesenchymal characteristics.

CircPDSS1 Promotes the Proliferation, Invasion, Migration, and EMT of Breast Cancer Cell via Regulating miR-320c/CKAP5 Axis

[Cancer Cell International] CircPDSS1 was upregulated in BC cells, and circPDSS1 knockdown repressed BC cell malignant behaviors.

Detection and Spatiotemporal Analysis of In Vitro 3D Migratory Triple-Negative Breast Cancer Cells

[Annals of Biomedical Engineering] Scientists present an image processing and segmentation pipeline for the detection of 3D GFP-fluorescent triple-negative breast cancer cell nuclei, and they performed quantitative analysis of the formed spatial patterns and their temporal evolution.

Dysregulation of Splicing Variants and Spliceosome Components in Breast Cancer

[Endocrine-Related Cancer] Investigators compile the current knowledge demonstrating the altered expression of splicing variants and spliceosomal components in BCa, showing the existence of a growing body of evidence supporting the close implication of the alteration in the splicing process in mammary tumorigenesis.

Glucose Deprivation Reduces Proliferation and Motility, and Enhances the Anti-Proliferative Effects of Paclitaxel and Doxorubicin in Breast Cell Lines In Vitro

[PLoS One] Scientists examined the effect of glucose as well as its deprivation, and antagonism using the non-metabolized analogue 2-deoxy glucose, on the proliferation of several breast cancer cell lines MCF7, MDA-MB-231, YS1.2 and pII and one normal breast cell line, using the MTT assay.

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Autophagy Regulates the Maturation of Hematopoietic Precursors in the Embryo

[Nature Communications] Using combined approaches, including scRNA-seq, researchers confirmed that autophagy-related gene 5 deletion interrupted developmental temporal order of endothelial to hematopoietic transition to further affect the pre-HSC I maturation.

Malignant Progression of Pre-Leukemic Disorders

[Blood] Scientists review the mechanisms of progression focusing on the hierarchy of clonal mutation and potential roles of transcription factor alterations, splicing factor mutations, and the bone marrow environment in progression to AML.

Alterations in Exocrine Pancreatic Function after Acute Pancreatitis

[Pancreatology] Investigators discuss the epidemiology, pathophysiology, and clinical management of exocrine pancreatic dysfunction after acute pancreatitis while highlighting key knowledge gaps.