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mladbrook
Mammary Cell News
Phenotypic Heterogeneity Driven by Plasticity of the Intermediate EMT State Governs Disease Progression and Metastasis in Breast Cancer
[Science Advances] Investigators isolated multiple distinct single-cell clones from the SUM149PT human breast cell line spanning the epithelial-to-mesenchymal transition spectrum having diverse migratory, tumor-initiating, and metastatic qualities, including three unique intermediates.
Mammary Cell News
Triple-Negative Breast Cancer Metastasis Involves Complex Epithelial-Mesenchymal Transition Dynamics and Requires Vimentin
[Science Translational Medicine] The authors demonstrated that spontaneous triple-negative breast cancer tumors from a genetically engineered mouse model, multiple patient-derived xenografts, and archival patient samples exhibited large populations in vivo of hybrid E/M cells that lead invasion ex vivo while expressing both epithelial and mesenchymal characteristics.
Mammary Cell News
CircPDSS1 Promotes the Proliferation, Invasion, Migration, and EMT of Breast Cancer Cell via Regulating miR-320c/CKAP5 Axis
[Cancer Cell International] CircPDSS1 was upregulated in BC cells, and circPDSS1 knockdown repressed BC cell malignant behaviors.
Mammary Cell News
Detection and Spatiotemporal Analysis of In Vitro 3D Migratory Triple-Negative Breast Cancer Cells
[Annals of Biomedical Engineering] Scientists present an image processing and segmentation pipeline for the detection of 3D GFP-fluorescent triple-negative breast cancer cell nuclei, and they performed quantitative analysis of the formed spatial patterns and their temporal evolution.
Mammary Cell News
Dysregulation of Splicing Variants and Spliceosome Components in Breast Cancer
[Endocrine-Related Cancer] Investigators compile the current knowledge demonstrating the altered expression of splicing variants and spliceosomal components in BCa, showing the existence of a growing body of evidence supporting the close implication of the alteration in the splicing process in mammary tumorigenesis.
Mammary Cell News
Glucose Deprivation Reduces Proliferation and Motility, and Enhances the Anti-Proliferative Effects of Paclitaxel and Doxorubicin in Breast Cell Lines In Vitro
[PLoS One] Scientists examined the effect of glucose as well as its deprivation, and antagonism using the non-metabolized analogue 2-deoxy glucose, on the proliferation of several breast cancer cell lines MCF7, MDA-MB-231, YS1.2 and pII and one normal breast cell line, using the MTT assay.
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Lipoic Acid Functions in Paneth Cells to Prevent Human Intestinal Stem Cell Aging
[Nature Communications] Scientists discerned that the effect of α-lipoic acid on mitigating intestinal stem cell (ISC) aging is contingent upon the presence of Paneth cells.
MTCH2 Deficiency Promotes E2F4/TFRC-Mediated Ferroptosis and Sensitizes Colorectal Cancer Liver Metastasis to Sorafenib
[Advanced Science] Investigators revealed the mechanism of mitochondrial carrier homolog 2 (MTCH2) deficiency-induced ferroptosis to inhibit the progression of colorectal cancer.
EZH2 Loss Promotes Gastric Squamous Cell Carcinoma
[Nature Communications] Researchers performed genomics analyses of twenty gastric squamous cell carcinoma samples and found that epigenetic regulation genes are among the most frequently mutated genes, including enhancer of zeste homolog 2 (EZH2).