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mladbrook

VDAC1 Negatively Regulates Melanogenesis through the Ca2+-Calcineurin-CRTC1-MITF Pathway

[Life Science Alliance] Knockdown of VDAC1 increased free cytosolic Ca2+ in cultured melanocytes at the resting state, which activated calcineurin through the Ca2+-calmodulin-CaN pathway.

ROS-Triggered Nanoinducer Based on Dermatan Sulfate Enhances Immunogenic Cell Death in Melanoma

[Journal of Controlled Release] Scientists proposed a nanoinducer based on a functional dermatan sulfate (DS) for melanoma. This nanosystem is composed of DS as framework, aromatic thioketal derivative as functional grafting unit and doxorubicin designed as an immunogenic cell death inducer.

Embigin is a Fibronectin Receptor that Affects Sebaceous Gland Differentiation and Metabolism

[Developmental Cell] Using skin as a model system and combining single-cell RNA-seq data analysis, immunofluorescence, and transgenic mouse models, investigators showed that the transmembrane protein embigin is specifically expressed in the sebaceous gland and that the number of embigin-expressing cells is negatively regulated by Wnt.

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Targeting EMT Using Low-Dose Teniposide by Downregulating ZEB2-Driven Activation of RNA Polymerase I in Breast Cancer

[Cell Death & Disease] Researchers demonstrated Teniposide as a potent modulator of the epithelial–mesenchymal transition (EMT) program, specifically through an interferon regulatory factor 7 (IRF7)–N-myc and STAT interactor (NMI) mediated response.

A Prismatic View of the Epigenetic-Metabolic Regulatory Axis in Breast Cancer Therapy Resistance

[Oncogene] The authors discuss interconnected epigenetic and metabolic regulatory pathways and then integrate them into an observable cancer metabolism-therapy-resistance axis that may inform clinical intervention.

SUCNR1 Regulates Insulin Secretion and Glucose Elevates the Succinate Response in People with Prediabetes

[Journal Of Clinical Investigation] Scientists reported that the succinate receptor (SUCNR1) was expressed in β-cells and was up-regulated in hyperglycemic states in mice and humans.