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VDAC1 Negatively Regulates Melanogenesis through the Ca2+-Calcineurin-CRTC1-MITF Pathway

[Life Science Alliance] Knockdown of VDAC1 increased free cytosolic Ca2+ in cultured melanocytes at the resting state, which activated calcineurin through the Ca2+-calmodulin-CaN pathway.

ROS-Triggered Nanoinducer Based on Dermatan Sulfate Enhances Immunogenic Cell Death in Melanoma

[Journal of Controlled Release] Scientists proposed a nanoinducer based on a functional dermatan sulfate (DS) for melanoma. This nanosystem is composed of DS as framework, aromatic thioketal derivative as functional grafting unit and doxorubicin designed as an immunogenic cell death inducer.

Embigin is a Fibronectin Receptor that Affects Sebaceous Gland Differentiation and Metabolism

[Developmental Cell] Using skin as a model system and combining single-cell RNA-seq data analysis, immunofluorescence, and transgenic mouse models, investigators showed that the transmembrane protein embigin is specifically expressed in the sebaceous gland and that the number of embigin-expressing cells is negatively regulated by Wnt.

Proximity between LAG-3 and the T Cell Receptor Guides Suppression of T Cell Activation and Autoimmunity

[Cell] To exploit LAG-3’s proximity to T cell receptor (TCR) and maximize LAG-3-dependent T cell suppression, scientists developed an Fc-attenuated LAG-3/TCR inhibitory bispecific antibody to bypass the requirement of cognate peptide-MHC class II.

Chemosensor Receptors Are Lipid-Detecting Regulators of Macrophage Function in Cancer

[Nature Immunology] Researchers conducted an unbiased genome-wide CRISPR screen of primary macrophages. Their study confirmed the function of known regulators in tumor associated macrophage responses and revealed new insights into the behavior of these cells.

A Genome-Wide Association Study Integrated With Single-Cell and Bulk Profiles Uncovers Susceptibility Genes for Nasopharyngeal Carcinoma Involved in Tumorigenesis Via Regulation of T Cells

[Genome Biology] Scientists performed in-depth bioinformatic analysis and functional experiments for EOMES, finding that the nasopharyngeal carcinoma-risk alleles of four functional SNPs upregulate EOMES expression by promoting the activity of regulatory elements in T cells.

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