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[Journal of Cosmetic Dermatology] Researchers report that differentiation of keratinocyte is dependent on the level of miR-203 expression and that inhibition of miR-203 can increase the expression of survivin, an epidermal marker of stemness.

[Nature Communications] Researchers established functional hallmarks of NRAS mutants enriched in human melanoma. They generated eight conditional, knock-in mouse models and showed that rare melanoma mutants are poor drivers of spontaneous melanoma formation, whereas common melanoma mutants induced rapid tumor onset with high penetrance.

[Experimental Dermatology] Scientists clarified the specific role of thrombospondin 1 (TSP1) in keloids and explored the potential mechanism. They demonstrated that TSP1 was highly expressed in keloid lesions compared to normal skin.

[OliX Pharmaceuticals, Inc. (Business Wire)] OliX Pharmaceuticals, Inc. announced the completion of patient enrollment in the Phase IIa clinical trial of OLX101A, an investigational therapeutic program for the treatment of hypertrophic scar.

[International Journal of Molecular Medicine] In a 3D multicellular system, obtained co‑culturing melanoma cancer cells with stromal cells, including ECs, melanoma ALDH1A1 overexpression induced the recruitment of ECs into the core of the tumorspheres.

[Experimental Dermatology] Researchers found a significant downregulation of secreted frizzled-related protein 1 (SFRP1) in HaCaT, A431, and SCL-1 cells after ultraviolet radiation B (UVB) irradiation.