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[HemaSphere] The authors discuss recent insights into the regulatory roles of cellular metabolism in HSCs. Understanding the metabolic requirements of healthy HSCs is of critical importance to the development of new therapies for hematological disorders.

[Scientific Reports] Recently, scientists adapted gastruloid culture conditions to promote cardiovascular development. In this work, they extended these conditions to capture features of embryonic blood development through a combination of immunophenotyping, detailed transcriptomics analysis, and identification of blood stem/progenitor cell potency.

[EMBO Journal] Researchers showed that in the zebrafish embryo, prostaglandin E2 synthesis genes are expressed by distinct stromal cell populations, myeloid, and endothelial cells of the caudal hematopoietic tissue.

[Nature Medicine] The authors report the preliminary results of an ongoing phase I/II trial evaluating safety and efficacy of gene editing therapy in children with blood transfusion-dependent β-thalassemia.

[Nature Communications] Scientists conditionally deleted Xist in hematopoietic system of mice and report differentiation and cell cycle defects in female hematopoietic stem and progenitor cells.

[Communications Biology] Investigators developed an intravital imaging method to visualize bone marrow in neonatal long bones formed by endochondral ossification which is essential for HSC niche formation.