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[Blood] Single-cell RNA-sequence analysis revealed that B-ALL induces a unique subset of CD4+ T cells with both cytotoxic and helper functions.

[Transplantation and Cellular Therapy ] Investigators described outcomes and examine risk factors for overall survival, leukemia-free survival, cumulative incidence of relapse, non-relapse mortality and graft-versus-host disease after allogeneic stem-cell transplantation for acute lymphoblastic leukemia in Brazilian centers.

[Haematologica] By ablating the B cell antigen receptor in chronic lymphocytic leukemia (CLL) cells from TCL1 transgenic mice, the authors showed that CLL cells cannot survive without BCR signaling and are lost within eight weeks in diseased mice.

[Haematologica] The authors investigated whether the genes showing abnormal expression in FLI1-deficient platelets could be involved in platelet α-granule biogenesis by undertaking transcriptome analysis of control platelets and platelets harboring a DNA-binding variant of FLI1.

[ACS Nano] Scientists reported on the design and evaluation of thrombin-loaded injury-site-targeted lipid nanoparticles that could specifically localize at an injury site via platelet-mimetic anchorage to the von Willebrand factor and collagen.

[Nature Communications] Researchers chart native lineage pathways emanating from HSCs and define their physiological regulation by computationally integrating experimental approaches for fate mapping, mitotic tracking, and single-cell RNA sequencing.