Hematopoiesis News Volume 13.37 | Sep 20 2022

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    2022-09-20 | HN 13.37


    Hematopoiesis News by STEMCELL Technologies
    Vol. 13.37 – 20 September, 2022
    TOP STORY

    Independent Origins of Fetal Liver Hematopoietic Stem and Progenitor Cells

    Researchers used in vivo genetic tracing in mice to analyze the formation of HSCs and progenitors from intra-arterial hematopoietic clusters, which contained HSC precursors and expressed the transcription factor hepatic leukemia factor.
    [Nature]

    Abstract
    ON1104SM-Small-Molecules-Wallchart-728x90
    PUBLICATIONSRanked by the impact factor of the journal

    Mitochondria Transfer Mediates Stress Erythropoiesis by Altering the Bioenergetic Profiles of Early Erythroblasts Through CD47

    To gain further insights into the mitochondria transfer functions, scientists infused erythroblastic island macrophages in vivo into mice subjected to different modes of anemic stresses.
    [Journal of Experimental Medicine]

    Abstract

    Allogeneic Hematopoietic Cell Transplant in Patients with Relapsed/Refractory Anaplastic Large Cell Lymphoma

    Non-relapse mortality, disease relapse/progression, progression-free surviva, and overall survival were modeled using Cox proportional hazards models.
    [British Journal of Haematology]

    Abstract

    Association between Abnormal Lipid Profile and Inflammation and Progression of Myelodysplastic Syndrome to Acute Leukemia

    Scientists investigated the association between abnormal lipid profiles and inflammation in myelodysplastic syndrome, which shared many genetic mutations with clonal hematopoiesis of indeterminate potential, and the risk of developing acute leukemia.
    [Experimental Hematology & Oncology]

    Full Article

    Expression of BCL11A in Chronic Lymphocytic Leukemia

    The expression of BCL11A was analyzed in peripheral blood mononuclear cells of 87 newly-diagnosed chronic lymphocytic leukemia patients by qRT-PCR, and association with clinical and molecular variables was assessed.
    [International Journal of Laboratory Hematology]

    Abstract

    Trends in Outcome of Transplantation in Patients with Secondary Acute Myeloid Leukemia: An Analysis From the Acute Leukemia Working Party (ALWP) of the EBMT

    Researchers evaluated results of HSCT in 4224 patients with sAML in complete remission; 1337 were transplanted in 2000–2010 and 2887 in 2011–2020. Median age was 54 and 59 ears, respectively
    [Bone Marrow Transplantation]

    Abstract

    Genetic Correction of Haemoglobin E in an Immortalised Haemoglobin E/Beta-Thalassaemia Cell Line Using the CRISPR/Cas9 System

    Scientists reported a highly efficient genetic correction of haemoglobin E mutation in the immortalised erythroid cell line cells using the CRISPR/Cas9 system.
    [Scientific Reports]

    Full Article

    Long-Term Follow-Up of Autologous Peripheral Blood Hematopoietic Stem Cell Transplantation for Refractory Lupus Nephritis—A Series Study of 20 Patients

    22 patients with lupus nephritis refractory to immunosuppressive therapy were enrolled. 20 patients were examined closely and two cases died within 100 days after autologous hematopoietic cell transplantation.
    [Lupus]

    Abstract
    Find out the estimated cell frequencies and percentages of more than 35 cell types in normal human blood-related sources.
    REVIEWS

    A Glycan-Based Approach to Cell Characterization and Isolation: Hematopoiesis as a Paradigm

    Using hematopoietic lineages as a paradigm, scientists leveraged the extraordinary molecular diversity of heparan sulfate glycans to establish cellular “glycotypes” by utilizing a panel of anti-HS single-chain variable fragment antibodies.
    [Journal of Experimental Medicine]

    Full Article

    Hox-Driven Conditional Immortalization of Myeloid and Lymphoid Progenitors: Uses, Advantages, and Future Potential

    Investigators review the use of Hoxb8 and Hoxa9 as hematopoietic regulators to conditionally immortalize murine hematopoietic progenitor cells which retained their ability to differentiate into many functional immune cell types including macrophages, neutrophils, basophils, osteoclasts, eosinophils, and dendritic cells.
    [Traffic]

    Abstract
    INDUSTRY AND POLICY NEWS

    BeiGene Receives Positive CHMP Opinion for BRUKINSA® (Zanubrutinib) for the Treatment of Adults with Marginal Zone Lymphoma

    BeiGene announced that the Committee for Medicinal Products for Human Use of the European Medicines Agency has issued a positive opinion recommending approval of BRUKINSA® for the treatment of adult patients with marginal zone lymphoma who have received at least one prior anti-CD20-based therapy.
    [BeiGene]

    Press Release
    FEATURED EVENT

    Type 2 Immunity in Homeostasis and Disease (2nd Edition)

    December 12 – 13, 2022
    Ghent, Belgium

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Researcher – Muscle, Endothelial, and Hematopoietic Cells

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    Postdoctoral Research Associate – Oncology

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    Postdoctoral Associate – Aging Hematopoiesis

    The Jackson Laboratory – Bar Harbor, Maine, United States

    Research Technologist – Tissue and Cell Biology

    STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada

    Senior Bioinformatics Research Scientist – Hematopoiesis and Blood Disorders

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    > See All Jobs

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