Hematopoiesis News Volume 13.42 | Oct 25 2022

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    Jamie Kang
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    2022-10-25 | HN 13.42


    Hematopoiesis News by STEMCELL Technologies
    Vol. 13.42- 25 October, 2022
    TOP STORY

    Phase II Trial of Daratumumab with DCEP in Relapsed/Refractory Multiple Myeloma Patients with Extramedullary Disease

    Scientists conducted a multicenter, non-randomized phase II trial of daratumumab in combination with dexamethasone, cyclophosphamide, etoposide and cisplatin (DARA-DCEP) to develop treatment for extramedullary multiple myeloma and multiple myeloma.
    [EMBO Journal]

    Full Article
    Request your free copy of the 'Directed Differentiation of Pluripotent Stem Cells' Wallchart
    PUBLICATIONSRanked by the impact factor of the journal

    Hematopoietic Stem and Progenitor Cells Integrate Microbial Signals to Promote Post-inflammation Gut Tissue Repair

    Researchers presented that acute gut inflammation expanded hematopoietic stem and progenitor cells in the bone marrow and directed them to inflamed mesenteric lymph nodes through GM–CSFR activation for further potential differentiation into Ly6C+/G+ myeloid cells specialized in gut tissue repair.
    [EMBO Journal]

    AbstractGraphical Abstract

    Srsf2P95H/+ Co-operates with Loss of TET2 to Promote Myeloid Bias and Initiate a Chronic Myelomonocytic Leukemia-Like Disease in Mice

    Based on human cancer genetics, an inducible Srsf2P95H/+ mutant model was crossed with Tet2fl/fl mice to mutate both concomitantly in HSCs.
    [Leukemia]

    Abstract

    Enhancing Regulatory T Cell Function via Inhibition of High Mobility Group Box 1 Protein Signaling in Immune Thrombocytopenia

    Researchers discovered that plasma High Mobility Group Box 1 Protein correlated negatively with platelet counts in immune thrombocytopenia (ITP) patients, and found that 18β-GA alleviated thrombocytopenia in ITP mice.
    [Haematologica]

    Abstract

    The Accumulation of miR-125b-5p Is Indispensable for Efficient Erythroblast Enucleation

    To elucidate the role of miR-125b-5p in erythroblast enucleation, researchers examined the endogenous expression of miR-125b-5p during erythropoiesis of hematopoietic stem/progenitor cells from both healthy controls and patients with polycythemia vera.
    [Cell Death & Disease]

    Full Article

    Role of Long Non-coding RNAs in Human Induced Pluripotent Stem Cells Derived Megakaryocytes: A p53, HOTAIRM1 and miR-125b Interaction Study

    Scientists developed a method to produce functional megakaryocytes from human-induced pluripotent stem cell-derived CD34+ HSCs under a feeder-free and xeno-free condition and minimized the risk and variation from the animal-derived products in cell cultures.
    [Journal of Pharmacology and Experimental Therapeutics]

    AbstractFull Article

    Systematic Molecular Profiling of Acute Leukemia Cancer Stem Cells Allows Identification of Druggable Targets

    Investigators developed a novel computational pipeline to analyze the transcriptomic profiles of AML cancer stem cells, and identified novel candidate markers and drug targets.
    [Heliyon]

    AbstractFull Article

    Lenalidomide and Eltrombopag for Treatment of Low or Intermediate Risk Myelodysplastic Syndrome: Result of a Phase II Clinical Trial

    Scientists tested if Eltrombopag (ELT) would reduce the incidence of thrombocytopenia in myelodysplastic syndrome by conducting a phase II multicenter trial of ELT and lenalidomide in adult patients.
    [Clinical Cancer Research]

    Abstract

    Bridging Advanced Myeloma Patients to Subsequent Treatments and Clinical Trials with Classical Chemotherapy and Stem Cell Support

    Researchers tested whether non-myeloablative chemotherapy with a stem cell boost provided disease control and hematopoietic improvement as a bridge to subsequent therapies.
    [Bone Marrow Transplantation]

    Abstract
    How to prioritize and manage your research projects
    REVIEWS

    TP53-Mutated Myelodysplastic Syndrome and Acute Myeloid Leukemia: Biology, Current Therapy, and Future Directions

    The authors discuss recent insights into the biology of TP53-mutated myelodysplastic syndrome and acute myeloid leukemia, current treatments, and emerging therapies, including immunotherapeutic and nonimmune-based approaches for this entity.
    [Cancer Discovery]

    Abstract

    Central Nervous System Involvement in Childhood Acute Lymphoblastic Leukemia: Challenges and Solutions

    Investigators discuss the challenges of childhood acute lymphoblastic leukemia therapy like measuring central nervous system leukemic load and current therapy associated with neurotoxicity, as well as highlight research advances aiming to provide solutions.
    [Leukemia]

    Full Article
    INDUSTRY AND POLICY NEWS

    Bio-Path Holdings Announces First Patient Dosed in Phase I/Ib Study of BP1002 in Refractory/Relapsed Acute Myeloid Leukemia Patients

    Bio-Path Holdings, Inc. announced the enrollment and dosing of the first patient in a Phase I/Ib clinical trial evaluating the ability of BP1002 to treat refractory/relapsed AML patients.
    [Bio-Path Holdings, Inc.]

    Press Release

    Mendus Secures Manufacturing Partner for Establishing Potential Pivotal Trial-Stage and Commercial Production of DCP-001

    Mendus AB announced an agreement to enable the technology transfer for manufacturing of DCP-001, the company’s lead development program, with Minaris Regenerative Medicine GmbH. DCP-001 is being evaluated in a Phase II clinical trial to prevent cases of tumour recurrence in AML.
    [Mendus AB]

    Press Release
    FEATURED EVENT

    Lund Stem Cell Center 20th Anniversary

    April 17 – 19, 2023
    Lund, Sweden

    > See All Events

    JOB OPPORTUNITIES

    Assistant Professor – Immunotherapy and Cellular Therapies

    The University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    Assistant Professor – Pediatric Hematology

    Medical College of Wisconsin – Milwaukee, Wisconsin, United States

    Research Associate – Aplastic Anaemia Pathophysiology

    King’s College London – London, England, United Kingdom

    Postdoctoral Position – Computational Biology

    Beth Israel Deaconess Medical Center – Boston, Massachusetts, United States

    Research Specialist – Megakaryopoiesis

    Karolinska Institutet – Stockholms, Sweden

    > See All Jobs

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