 | | Vol. 13.43 – 1 November, 2022 |
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| Researchers used Hi-C and whole-genome sequencing to analyze 25 samples from patients with AML and seven samples from healthy donors to understand the extent to which mutations in AML drove alterations in chromatin 3D structure and contributed to myeloid transformation.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists reported that Ubiquitin-like containing PHD Ring Finger 1 (UHRF1), an epigenetic regulator that recruits DNMT1 to methylate DNA, was highly expressed in AML and predicted poor prognosis.
[Cell Research] |
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| Investigators discovered that an RNA N6-methyladenosine methyltransferase, METTL16, played an essential role in proper erythropoiesis by safeguarding genome integrity via the control of DNA-repair-related genes.
[Nature Communications] |
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| The authors documented that innate lymphoid cells existed in Rag2−/−Il2rg−/− recipients engrafted with pluripotent stem cell-derived hematopoietic progenitors guided by Runx1 and Hoxa9 expression.
[Cell Reports] |
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| To establish a paradigm for multiplexed gene editing in primary human cord blood-derived hematopoietic stem and progenitor cells, scientists used co-delivery of lentiviral sgRNA vectors, together with Cas9 mRNA, to simultaneously edit two genetic loci.
[Scientific Reports] |
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| Investigators demonstrated that pharmacological activation of G protein-coupled estrogen receptor by G-1 combined with Venetoclax resulted in synergistic antileukemic activity in vitro and in vivo.
[Cell Death & Disease] |
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| The loss- and gain-of-function experiments demonstrated that RAB3D promoted growth, enhanced colony formation, and accelerated G1/S transition of U937, THP-1, and KG-1 in AML cells.
[Cancer Gene Therapy] |
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| Scientists compared the effect of dimethoxycurcumin and curcumin on a variety of histone posttranslational modifications and on the activity of histone lysine methyltransferase and demethylase enzymes that targeted the H3K4, H3K9, and H3K27 epigenetic marks in leukemia cells.
[Journal of Cellular and Molecular Medicine] |
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| A total of 112 AML patients were enrolled in the study. Induction therapy consisting of Azacitidine was given in combination with the HAG (Homoharringtonine, low-dose cytarabine, G-CSF) regimen.
[Blood Cancer Journal] |
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| To determine how mutations other than those in the ABL1 gene affect chronic myeloid leukemia (CML) prognosis, researchers identified 115 patients with CML where targeted next-generation sequencing of genes recurrently mutated in myeloid leukemias was performed.
[Blood Cancer Journal] |
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| The authors summarize results that indicate that the marrow pluripotent hematopoietic stem cell is actively cycling and thus, continually changing phenotype.
[Leukemia] |
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| Scientists discuss the pathogenesis and management of accelerated and blast phases of chronic myeloid leukemia, both of which have a relatively poor prognosis.
[Leukemia] |
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| The FDA granted accelerated approval to Tecvayli, Janssen Biotech, Inc., the first bispecific B-cell maturation antigen-directed CD3 T cell engager, for adult patients with relapsed or refractory multiple myeloma.
[US FDA] |
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| March 6 – 8, 2023
Paris, France |
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| | University of British Columbia – Vancouver, British Columbia, Canada |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Karolinska Institutet – Flemingsberg, Sweden |
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| | The University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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