Hematopoiesis News Volume 13.44 | Nov 08 2022

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    Noshin Noorjahan
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    2022-11-08 | HN 13.44


    Hematopoiesis News by STEMCELL Technologies
    Vol. 13.44 – 8 November, 2022
    TOP STORY

    MIR Retrotransposons Link the Epigenome and the Transcriptome of Coding Genes in Acute Myeloid Leukemia

    Using a systems approach within topologically associating domains, researchers found enriched correlations between gene expression and methylation in signaling and metabolic pathways where most genes had mammalian interspersed repeat (MIR) retrotransposons in their introns.
    [Nature Communications]

    Full Article
    Free E-Book: Genome Editing Applications for Disease Modeling and Cell Therapy.
    PUBLICATIONSRanked by the impact factor of the journal

    Identification of Hematopoietic Stem Cells Residing in the Meninges of Adult Mice at Steady State

    Investigators reported that steady-state meninges of adult mice hosted HSCs, as defined by long-term, efficient, multi-lineage reconstitution, and self-renewal capacity in the meninges, blood, spleen, and bone marrow of sublethally irradiated adult recipients.
    [Cell Reports]

    Full ArticleGraphical Abstract

    GATA-3 Is a Proto-Oncogene in T Cell Lymphoproliferative Neoplasms

    The authors showed that GATA-3 was a proto-oncogene across the spectrum of T cell neoplasms, and further defined the transcriptional programs that were GATA-3 dependent, which included therapeutically targetable gene products.
    [Blood Cancer Journal]

    Full Article

    Role of Reactive Oxygen Species in Regulating 27-Hydroxycholesterol-Induced Apoptosis of Hematopoietic Progenitor Cells and Myeloid Cell Lines

    Scientists reported that exogenous 27-hydroxycholesterol treatment led to a substantial reduction in the hematopoietic stem and progenitor cell population owing to significantly increased reactive oxygen species levels and apoptosis in the bone marrow.
    [Cell Death & Disease]

    Full Article

    The snoRNA-Like lncRNA LNC-SNO49AB Drives Leukemia by Activating the RNA-Editing Enzyme ADAR1

    Researchers identified a novel small nucleolar RNA (snoRNA)-related long noncoding RNA (lncRNA) named LNC-SNO49AB and showed that LNC-SNO49AB represented an unreported type of lncRNA with a 5′-end m7G and a 3′-end snoRNA structure.
    [Cell Discovery]

    Full Article

    Maternal Western-Style Diet Remodels the Transcriptional Landscape of Fetal Hematopoietic Stem and Progenitor Cells in Rhesus Macaques

    The authors analyzed the transcriptional landscape of fetal bone marrow hematopoietic stem and progenitor cells at single-cell resolution in fetal macaques exposed to a maternal high-fat Western-style diet or a low-fat control diet.
    [Stem Cell Reports]

    Full ArticlePress ReleaseGraphical Abstract

    Screening of Chimeric GAA Variants in a Preclinical Study of Pompe Disease Results in Candidate Vectors for Hematopoietic Stem Cell Gene Therapy

    Lentiviral vector-mediated hematopoietic stem and progenitor cell gene therapy was investigated in a Pompe mouse model using a clinically relevant promoter driving nine engineered acid alpha-glucosidase (GAA) coding sequences incorporating distinct peptide tags and codon-optimizations.
    [Molecular Therapy-Methods & Clinical Development]

    Full ArticleGraphical Abstract

    Cytokines Help Suggest Aplastic Anemia with Pulmonary Bacterial or Co-Fungal Infection

    Pulmonary infection can worsen aplastic anemia (AA). Hence, to find biomarkers predicting bacterial or bacterial-combined fungal infections in the lungs, scientists reviewed 287 AA medical records with and without bacterial and fungal infections.
    [Scientific Reports]

    Full Article

    Pure (Acute) Erythroid Leukemia: Morphology, Immunophenotype, Cytogenetics, Mutations, Treatment Details, and Survival Data among 41 Mayo Clinic Cases

    Investigators identified 41 Mayo Clinic cases of pure erythroid leukemia and provided a comprehensive account of bone marrow morphology, immunophenotype, cytogenetic, and mutation profiles.
    [Blood Cancer Journal]

    Full Article

    Patient- and Physician-Reported Pain after Tyrosine Kinase Inhibitor Discontinuation among Patients with Chronic Myeloid Leukemia

    Researchers plotted the trajectory of chronic myeloid leukemia patient-reported pain over time using a piecewise mixed-effects ordinal logistic model after discontinuation of tyrosine kinase inhibitor therapy.
    [Haematologica]

    Full Article

    Interstitial Lung Diseases after Hematopoietic Stem Cell Transplantation: New Pattern of Lung Chronic Graft-versus-Host Disease?

    To determine if interstitial lung diseases (ILDs) belonged to the spectrum of lung chronic graft-versus-host disease like bronchiolitis obliterans syndrome (BOS), scientists compared characteristics and specific risk factors for both ILD and BOS by analyzing data collected from patients diagnosed with ILD or BOS.
    [Bone Marrow Transplantation]

    Full Article
    Activate, expand, and differentiate your cells with cytokines, chemokines, and growth factors from STEMCELL Technologies.
    REVIEWS

    Cell-Intrinsic Factors Governing Quiescence vis-à-vis Activation of Adult Hematopoietic Stem Cells

    The authors review the dominantly acting intrinsic factors governing quiescence vis-à-vis activation of the HSCs in the face of external forces acting on them.
    [Molecular and Cellular Biochemistry]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    The NRC’s Human Health Therapeutics Research Centre Receives Funding for Pediatric Cancer Research

    The National Research Council of Canada’s (NRC) Human Health Therapeutics Research Centre was awarded a $1.66 million grant to conduct research on pediatric acute lymphoblastic leukemia.
    [National Research Council Canada]

    Press Release
    FEATURED EVENT

    ESMO Targeted Anticancer Therapies Congress 2023

    March 6 – 8, 2023
    Paris, France

    > See All Events

    JOB OPPORTUNITIES

    Faculty Position – Division of Hematology

    Washington University School of Medicine – St. Louis, Missouri, United States

    Investigator – Hematopoiesis

    Blood Center of Wisconsin – Milwaukee, Wisconsin, United States

    PhD Studentship – Cancer Evolution

    German Cancer Research Center in the Helmholtz Association – Munich, Germany

    Staff Scientist – Bioinformatics

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Position – Cancer Immunotherapy

    Karolinska Institutet – Flemingsberg, Sweden

    > See All Jobs

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