Hematopoiesis News Volume 13.47 | Dec 06 2022

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    Jamie Kang
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    2022-12-06 | HN 13.47


    Hematopoiesis News by STEMCELL Technologies
    Vol. 13.47 – 6 December, 2022
    TOP STORY

    Mutant NPM1 Hijacks Transcriptional Hub to Maintain Pathogenic Gene Programs in Acute Myeloid Leukemia

    For the first time, scientists comprehensively demonstrated nucleophosmin (NPM1c) bonded to a subset of active gene promoters in NPM1c AMLs, including well-known leukemia-driving genes – HOXA/B cluster genes and MEIS1.
    [Cancer Discovery]

    Abstract
    Explore this validated protocol for high-efficiency CRISPR-Cas9 gene editing of Human Primary T Cells.
    PUBLICATIONSRanked by the impact factor of the journal

    Transient Regulation of RNA Methylation in Human Hematopoietic Stem Cells Promotes Their Homing and Engraftment

    Researchers demonstrated that inhibition of RNA decay by regulation of RNA methylation enhanced the expression of the homing receptor chemokine C-X-C receptor-4 in HSCs.
    [Leukemia]

    Full Article

    The ENL YEATS Epigenetic Reader Domain Critically Links MLL-ENL to Leukemic Stem Cell Frequency in t(11; 19) Leukemia

    Scientists found the YEATS domain was retained in 84.1% of MLL-ENL patients and crucial for MLL-ENL-mediated leukemogenesis in mouse models. Mechanistically, deletion of the YEATS domain impaired MLL-ENL fusion protein binding and decreased expression of pro-leukemic genes like Eya1 and Meis1.
    [Leukemia]

    Abstract

    IMPDH Inhibition Activates TLR-VCAM1 Pathway and Suppresses the Development of MLL-Fusion Leukemia

    The authors found that AMLs with MLL-fusions were susceptible to inosine monophosphate dehydrogenase (IMPDH) inhibitors in vitro.
    [EMBO Molecular Medicine]

    Full ArticleGraphical Abstract

    Modular UBE2H-Ctlh E2-E3 Complexes Regulate Erythroid Maturation

    By measuring the proteomic landscape of in vitro human erythropoiesis models, investigators found dynamic differential expression of subunits of the CTLH E3 ubiquitin ligase complex that formed maturation stage-dependent assemblies of topologically homologous RANBP9- and RANBP10-CTLH complexes.
    [eLife]

    Full Article

    HDAC1/3-Dependent Moderate Liquid–Liquid Phase Separation of YY1 Promotes METTL3 Expression and AML Cell Proliferation

    Researchers uncovered that Yin Yang 1 (YY1) bonded to the promoter region of METTL3 as a transcription factor and promoted its expression, which in turn enhanced the proliferation of AML cells.
    [Cell Death & Disease]

    Full Article

    Total Body Irradiation plus Fludarabine versus Busulfan plus Fludarabine as a Myeloablative Conditioning for Adults with Acute Myeloid Leukemia Treated with Allogeneic Hematopoietic Cell Transplantation. A Study on Behalf of the Acute Leukemia Working Part of the EBMT

    Investigators compared retrospectively, total body irradiation plus fludarabine (Flu) versus busulfan plus Flu as myeloablative conditioning before allogeneic hematopoietic cell transplantation in patients with AML.
    [Bone Marrow Transplantation]

    Abstract

    Predicting the Loss of Hepatitis B Surface Antigen Following Hematopoietic Stem Cell Transplantation in Patients with Chronic HBV Infection

    A total of 62 patients with chronic hepatitis B virus infection achieved hepatitis B surface antigen loss after allogeneic hematopoietic stem cell transplantation.
    [Bone Marrow Transplantation]

    Abstract

    Paired Bone Marrow and Peripheral Blood Samples Demonstrate Lack of Widespread Dissemination of Some CH Clones

    Researchers showed that patients with osteoarthritis had a high prevalence of clonal hematopoiesis (CH), involving genes encoding epigenetic modifiers and DNA damage repair pathway proteins.
    [Blood Advances]

    Abstract
    Easy250 EasySep Magnet for rapid immune cell isolation from large-volume samples.
    REVIEWS

    CHIP Happens: Clonal Hematopoiesis of Indeterminate Potential and Its Relationship to Solid Tumors

    The authors review the role of clonal hematopoiesis of indeterminate potential (CHIP) mutations in clonal expansion of hematopoietic cells, explore the relationship between CHIP and solid tumors, and discuss the potential roles of CHIP in inflammation and solid tumor biology.
    [Clinical Cancer Research]

    Abstract

    The Present and Future of Measurable Residual Disease Testing in Acute Myeloid Leukemia

    Researchers review the current approaches to measurable residual disease (MRD) testing in AML, discuss strengths and limitations, highlight recent technological advances that may improve such testing, and summarize ongoing initiatives to advance the use of MRD testing in patients with AML.
    [Haematologica]

    Full Article
    INDUSTRY AND POLICY NEWS

    Tonix Pharmaceuticals Announces Collaboration with Boston Children’s Hospital to Study Tnx-1500 (FC-Modified Anti-CD40L mAb) for the Prevention of Graft-versus-Host Disease (GvHD) Following Hematopoietic Stem Cell Transplantation in Animals

    Tonix Pharmaceuticals Holding Corp. announced that it entered into a sponsored research agreement with Boston Children’s Hospital to study TNX-15001 (Fc-modified anti-CD40L mAb) for the prevention of graft-versus-host diseases after hematopoietic stem cell transplantation in animals.
    [Tonix Pharmaceuticals Holding Corp.]

    Press Release

    Imago BioSciences Announces First Participant Dosed in Investigator-Sponsored Phase I Study of Bomedemstat in Combination with Venetoclax in Relapsed/Refractory Acute Myeloid Leukemia

    Imago BioSciences, Inc. announced that the first participant had been dosed in an investigator-sponsored Phase I study of bomedemstat, an investigational oral lysine-specific demethylase 1 inhibitor, in combination with venetoclax (Venclexa®) in patients with relapsed or refractory AML.
    [Imago BioSciences, Inc.]

    Press Release
    FEATURED EVENT

    AACR Special Conference: Acute Myeloid Leukemia and Myelodysplastic Syndrome

    January 23 – 25, 2023
    Austin, Texas, United States

    > See All Events

    JOB OPPORTUNITIES

    Professor – Experimental Hematology

    RWTH Aachen University – Aachen, Germany

    Senior Director – Therapeutic Area Quality

    Bristol Myers Squibb – Uxbridge, England, United Kingdom

    Postdoctoral Research Associate – Human Umbilical Cord Blood

    University of Edinburgh – Edinburgh, Scotland, United Kingdom

    Postdoctoral Positions – Cancer/Leukemia Stem Cells

    Icahn School of Medicine at Mount Sinai – New York City, New York, United States

    Postdoctoral Fellowship – Signaling Pathways in Hematopoiesis

    Stanford University – Stanford, California, United States

    > See All Jobs

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