Hematopoiesis News Volume 13.48 | Dec 13 2022

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    Noshin Noorjahan
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    2022-12-13 | HN 13.48


    Hematopoiesis News by STEMCELL Technologies
    Vol. 13.48 – 13 December, 2022
    TOP STORY

    Temporal Molecular Program of Human Hematopoietic Stem and Progenitor Cells after Birth

    Researchers reported a transcriptional census of human bone-marrow-derived hematopoietic stem and progenitor cells from the neonate, infant, child, adult, and aging stages, showing two subpopulations of multipotent progenitors separated by CD52 expression.
    [Developmental Cell]

    AbstractGraphical Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Oncogenic Deubiquitination Controls Tyrosine Kinase Signaling and Therapy Response in Acute Lymphoblastic Leukemia

    Scientists revealed a posttranslational regulation of kinase signaling and nuclear receptor activity via deubiquitination in T cell acute lymphoblastic leukemia.
    [Science Advances]

    Full Article

    The Transcription Factor DDIT3 Is a Potential Driver of Dyserythropoiesis in Myelodysplastic Syndromes

    Investigators analyzed the transcriptome of human HSCs purified from young and older healthy adults, as well as myelodysplastic syndromes patients, identifying transcriptional alterations following different patterns of expression.
    [Nature Communications]

    Full Article

    Myeloid Cells Promote Interferon Signaling-Associated Deterioration of the Hematopoietic System

    The authors interrogated the contribution of myeloid cells, the most abundant cell type in the mammalian bone marrow, in a clinically relevant mouse model of neutropenia.
    [Nature Communications]

    Full Article

    CD34dim Cells Identified as Pluripotent Stem Cell-Derived Definitive Hemogenic Endothelium Purified Using Bone Morphogenetic Protein 4

    Scientists identified and validated a CD34dim subpopulation with hemogenic potential. They also purified CD34 cells with a CXCR4−CD73−phenotype as a definitive hemogenic endothelium population that generated HSCs and lymphocytes.
    [Cell Proliferation]

    Full Article

    Splicing Factor Deficits Render Hematopoietic Stem and Progenitor Cells Sensitive to STAT3 Inhibition

    Using zebrafish, researchers showed that hematopoietic stem and progenitor cell formation in sf3b1 homozygous mutants was dependent on STAT3 activation.
    [Cell Reports]

    Full Article

    Adipocytes Control Hematopoiesis and Inflammation through CD40 Signaling

    Investigators delineated the role of adipocyte-CD40 in the aging hematopoietic system and evaluated the effects of adipocyte CD40 deficiency on cardiometabolic diseases.
    [Haematologica]

    Abstract

    Impairment of FOXM1 Expression in Mesenchymal Cells from Patients with Myeloid Neoplasms, De Novo and Therapy-Related, May Compromise Their Ability to Support Hematopoiesis

    Scientists investigated the expression of the FOXM1 gene in bone marrow mesenchymal stem cells (BM-MSCs) isolated from patients with myelodysplastic syndromes and AML and compared it to BM-MSCs isolated from healthy donors.
    [Scientific Reports]

    Full Article

    Overlapping Features of Therapy-Related and De Novo NPM1-Mutated AML

    The authors compared the genetics, transcriptional profile, and clinical outcome of therapy-related NPM1-mutated AML, de novo NPM1-mutated AML, and therapy-related AML with wild-type NPM1.
    [Blood]

    Abstract

    Image of man completing the on-demand CFU assay course on his laptop.
    REVIEWS

    DDX41-Associated Susceptibility to Myeloid Neoplasms

    Deleterious germline DDX41 variants confer risk for myeloid neoplasms (MNs), and less frequently to lymphoid malignancies, with autosomal dominant inheritance and an estimated prevalence of 3% among MNs.
    [Blood]

    Abstract

    The Path to Venetoclax Resistance Is Paved with Mutations, Metabolism, and More

    Investigators summarize the emerging mechanisms of resistance to venetoclax treatment, discuss the promising combination strategies, and highlight the combinations that are currently in clinical trials.
    [Science Translational Medicine]

    Abstract

    Central Nervous System Prophylaxis and Treatment in Acute Leukemias

    In addition to treatment with CNS-penetrant systemic therapy, intrathecal prophylaxis is indicated in all patients with acute lymphoblastic leukemia, however, is not uniformly administered in patients with AML without high-risk features.
    [Current Treatment Options in Oncology]

    Full Article
    INDUSTRY AND POLICY NEWS

    NIH Plans Grant-Review Overhaul to Reduce Bias

    The US National Institutes of Health (NIH) has released a tentative plan to change how its research grant applications are scored, with the aim of reducing bias and lowering the burden on reviewers.
    [Nature]

    Press Release
    FEATURED EVENT

    AACR Special Conference: Pediatric Hematologic Malignancies

    February 19 – 22, 2023
    New Orleans, Louisiana, United States

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    JOB OPPORTUNITIES

    Research Associate – Hematological Malignancy

    University Health Network – Toronto, Ontario, Canada

    Postdoctoral Scientist – Genomic Informatics

    University of Oxford – Oxford, England, United Kingdom

    Postdoctoral Fellowship – Signaling Pathways in Hematopoiesis

    Stanford University – Stanford, California, United States

    Senior Director – Therapeutic Area Quality

    Bristol Myers Squibb – Uxbridge, England, United Kingdom

    Professor – Experimental Hematology

    RWTH Aachen University – Aachen, Germany

    > See All Jobs

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