 | | Vol. 14.02 – 17 January, 2023 |
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| Scientists performed fecal microbiota transplantation from young mice to aged mice and observed a significant increment in lymphoid differentiation and a decrease in myeloid differentiation in aged recipient mice.
[Blood] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| To understand the consequences and molecular mechanisms contributing to disease development and oncogenic transformation, investigators developed murine hematopoietic stem and progenitor cell models expressing mutated STAT3Y640F.
[Blood] |
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| Researchers carried out a genome-wide CRISPR-Cas9 guide RNA screen and identified tyrosine protein kinase receptor UFO, AXL, as a proteinaceous receptor for B19V infection of erythroid progenitor cells.
[Science Advances] |
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| The authors identified the soluble N-ethylmaleimide-sensitive factor attachment protein receptor Sec22b as a unique and critical regulator of plasma cell maintenance and function.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Scientists found that the E3 ligase-TRIM31 regulated HSC homeostasis and leukemia through the accumulation of CDK8. TRIM31 deficiency promoted hematopoietic stem and progenitor cell proliferation and long-term HSC exhaustion.
[Haematologica] |
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| Researchers hypothesized that the mutational status of bone marrow dysplastic cells and leukemic blasts, analyzed at the onset of AML using integrated multidimensional flow cytometry immunophenotyping and fluorescence-activated cell sorting with next-generation sequencing, could reconstruct leukemogenesis.
[Blood Advances] |
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| Investigators designed an allele-specific polymerase chain reaction (AS-PCR) with locked nucleic acid-modified primers. A cohort of 63 patients harboring heterozygous c.55_56insGAGTCG and c.415C > T NUDT15 variations was selected for haplotyping using AS-PCR.
[Scientific Reports] |
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| Researchers performed a cross-sectional analysis of platelet function in 25 SARS-CoV-2 and 10 healthy subjects by measuring Nox2-derived oxidative stress and thromboxane B2, and investigated if administration of monoclonal antibodies against the Spike protein of SARS-CoV-2 affects platelet activation.
[Circulation Research] |
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| Scientists analyzed the relation between clonal hematopoiesis of indeterminate potential status and incident peripheral artery disease and atherosclerosis, using whole-exome sequencing and clinical data from the UK Biobank and the Mass General Brigham Biobank.
[Nature Cardiovascular Research] |
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| The authors highlight the importance of bone marrow fibroblasts and mesenchymal stem cells in health and AML and their impact on patient prognosis.
[British Journal of Pharmacology] |
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| Investigators present information that show that platelet count can be used to predict long-term prognosis after chemotherapy, especially in the case of acute myeloid leukemia patients.
[Clinical and Experimental Medicine] |
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| Cellenkos, Inc. announced that the first patient was dosed in the Phase Ib LIMBER-TREG108 study evaluating CK0804 as an add-on therapy to ruxolitinib in patients with myelofibrosis who experience a suboptimal response to ruxolitinib.
[Cellenkos Inc. (Cision US Inc.)] |
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| February 21 – 23, 2023
London, England, United Kingdom |
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| | Hebrew University of Jerusalem – Jerusalem, Israel |
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| | Lund University – Lund, Sweden |
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| | Upstate Medical University – Syracuse, New York, United States |
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| | Stanford Medicine – Stanford, California, United States |
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| | US FDA – Silver Spring, Maryland, United States |
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