 | | Vol. 14.08 – 28 February, 2023 |
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| To determine whether phosphatidylinositol 3 kinase (PI3K) down-regulation can perturb HSC function, scientists generated a triple knockout mouse model with Pik3ca, Pik3cb, and Pik3cd deletion in hematopoietic cells.
[Science Advances] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| To test whether there are functional connections between expression of ABO blood group (BG) antigens and erythropoiesis regulation, researchers investigated hemoglobin and hematocrit values in BG B blood donors compared to BG A.
[Leukemia] |
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| Investigators performed a cross-sectional cohort study of 85 patients with severe lung disease undergoing transplantation to characterize clonal hematopoiesis prevalence. They evaluated somatic variants using duplex error-corrected sequencing and germline variants using whole exome sequencing.
[JCI Insight] |
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| The authors investigated the mechanism of breakpoint cluster region::Abelson murine viral homologue 1-independent dasatinib resistance. The expression and activation level of genes or proteins were evaluated using array CGH, real time PCR, or western blot analysis.
[Cell Proliferation] |
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| Cell counting kit-8 assays and Chou-Talalay’s combination index were used to examine the synergistic effect of Chidamide and Cladribine on AML cell lines and primary AML cells.
[Experimental Hematology & Oncology] |
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| Targeted RNA-sequencing was used to identify the novel subgroups of acute lymphoblastic leukemia (ALL) in 144 B-other and 40 classical ALL samples.
[Blood Advances] |
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| Investigators evaluated ovarian function, occurence of premature ovarian insufficiency, and spontaneous pregnancy in a large cohort of adult survivor women who had received HSC transplant for leukemia before puberty.
[Transplantation and Cellular Therapy] |
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| To better understand the clinical relevance and biological consequences of ubiquitin-like activating enzyme (UBA1)non-M41 variants, researchers analyzed the whole genome and transcriptome data of 4168 patients with hematological malignancies.
[Leukemia] |
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| Scientists retrospectively studied 97 AML patients with trisomy 19 (tris-19) treated between 2001 and 2019 within two multicenter study groups. Tris-19 occurred solely in 10, with additional abnormalities in non-complex karyotypes in 8 and within complex karyotypes in 79 patients.
[Haematologica] |
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| The authors describe the hematologic differences among neonatal subgroups and the major underlying pathogenic mechanisms. Issues that should be taken into account when interpreting neonatal hematological parameters are also highlighted.
[Annals of Hematology] |
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| AstraZeneca’s tablet formulation of Calquence has been approved in the European Union (EU) for the treatment of adult patients with chronic lymphocytic leukemia.
[AstraZeneca] |
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| April 14 – 19, 2023
Orlando, Florida, United States |
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| | German Cancer Research Center in the Helmholtz Association – Munich, Germany |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Duke University – Durham, North Carolina, United States |
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| | Hebrew University of Jerusalem – Jerusalem, Israel |
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Cancer Stem Cell News
Cell Therapy News
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