Hematopoiesis News Volume 14.09 | Mar 07 2023

    By
    Jamie Kang
    -
    0
    21







    2023-03-07 | HN 14.09


    Hematopoiesis News by STEMCELL Technologies
    Vol. 14.09 – 7 March, 2023
    TOP STORY

    Chemically Defined Cytokine-Free Expansion of Human Hematopoietic Stem Cells

    Investigators reported the establishment of a culture system that allowed the long-term ex vivo expansion of human HSCs, achieved through the complete replacement of exogenous cytokines and albumin with chemical agonists and a caprolactam-based polymer.
    [Nature]

    Full ArticlePress Release
    PUBLICATIONSRanked by the impact factor of the journal

    USB1 Is a miRNA Deadenylase That Regulates Hematopoietic Development

    Researchers determined that USB1 removed extra adenosines from the 3′ end of microRNAs, which if not removed, promoted the degradation of microRNAs that are necessary for blood development.
    [Science]

    AbstractPress Release

    Endothelial and Leptin Receptor+ Cells Promote the Maintenance of Stem Cells and Hematopoiesis in Early Postnatal Murine Bone Marrow

    In early postnatal bone marrow, stem cell factor from LepR+/Prx1+ stromal cells promoted myeloid and erythroid progenitor maintenance, while stem cell factor from endothelial cells promoted HSC maintenance.
    [Developmental Cell]

    Full ArticleGraphical Abstract

    Nanoparticle-Mediated Targeting of the Fusion Gene RUNX1/ETO in t(8; 21)-Positive Acute Myeloid Leukemia

    Scientists described the use of siRNA-loaded lipid nanoparticles for the specific therapeutic targeting of the leukemic fusion gene RUNX1/ETO.
    [Leukemia]

    Full Article

    CD169-CD43 Interaction Is Involved in Erythroblastic Island Formation and Erythroid Differentiation

    Researchers generated CD169-CreERT knock-in mice and investigated the function of CD169 in erythroblastic island formation and erythropoiesis using CD169-null mice.
    [Haematologica]

    Abstract

    RNA Helicase DHX15 Exemplifies a Unique Dependency in Acute Leukemia

    Investigators highlighted the functional contribution of DHX15 to leukemogenesis through regulation of established oncogenic pathways.
    [Haematologica]

    Abstract

    Alcam-A and Pdgfr-α Are Essential for the Development of Sclerotome-Derived Stromal Cells That Support Hematopoiesis

    Scientists identified Alcama and Pdgfr-α as two essential transmembrane proteins in the process of stromal cell progenitors’ emergence from somite epithelial cells, their subsequent migration to become stromal cells, and the resulting structure and functionality of the caudal hematopoietic tissue niche.
    [Bone Marrow Transplantation]

    Full Article

    Improved Survival of Patients with Primary Plasma Cell Leukemia with VRd or Daratumumab-based Quadruplets: A Multicenter Study by the Greek Myeloma Study Group

    Researchers demonstrated that treatment with bortezomib-lenalidomide triple/daratumumab-based quadruplets induced deep and durable responses and was a strong prognostic factor for overall survival representing currently the best therapeutic option for primary plasma cell leukemia.
    [American Journal Of Hematology]

    Abstract

    Allogeneic Stem Cell Transplantation for Patients with Acute Myeloid Leukemia (AML) in Second Complete Remission (CR2) Transplanted from Unrelated Donors with Post-Transplant Cyclophosphamide (PTCy). A Study on Behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

    Investigators retrospectively evaluated transplant outcomes of adult AML patients transplanted between 2010–2019 from 9–10/10 human leukocyte antigen-matched unrelated donors in CR2.
    [Bone Marrow Transplantation]

    Abstract
    Scientific resources to support your hematopoiesis research. Learn More!
    REVIEWS

    Clinical Use of CAR T-cells in Treating Acute Lymphoblastic Leukemia

    The author reviews published data on the clinical use of CAR T-cells in treating acute lymphoblastic leukemia.
    [Transfusion And Apheresis Science]

    Abstract
    INDUSTRY AND POLICY NEWS

    FDA and EMA Grant Orphan Drug Designation to Mocravimod for the Treatment of Acute Myeloid Leukemia (AML) in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)

    Priothera announced that the US FDA and the European Medicines Agency had both granted orphan drug designation to mocravimod for the treatment of AML in patients undergoing allogeneic HSCT.
    [Priothera]

    Press Release
    FEATURED EVENT

    Cell Symposium: Viruses in Health and Disease

    March 19 – 21, 2023
    Sitges, Spain

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Researcher – Leukemic Niche

    Karolinska Institute – Solna, Sweden

    Postdoctoral Research Associate – Hematology

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    Postdoctoral Research Associate – Pharmaceutical Sciences

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    PhD Student – Cancer Evolution

    German Cancer Research Center in the Helmholtz Association – Munich, Germany

    Postdoctoral, Student, and Technician Positions – Stem-Immunology

    Harvard Medical School – Boston, Massachusetts, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Hematopoiesis News Twitter