 | | Vol. 14.12 – 28 March, 2023 |
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| Investigators showed that the oncogenic BCR-ABL1 of chronic myelogenous leukemia and the cellular ABL1 tyrosine kinases phosphorylated and inactivated Smad4 to block antiproliferative TGF-β signaling.
[Signal Transduction and Targeted Therapy] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| RNA interference was performed to understand the function of astakine in hematopoiesis and apoptosis in Litopenaeus vannamei under ammonia-N exposure.
[Science of The Total Environment] |
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| The authors integrated extensive longitudinal functional assessments of HSC-specific lineage tracing with single-cell transcriptome and epitope profiling.
[Cell Reports] |
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| Scientists found no differences in HSC function and hematopoiesis in latexin (Lxn) knockout male mice under physiologic and myelosuppressive conditions. They also found that thrombospondin 1, a downstream target gene of Lxn in female HSCs, was repressed in male HSCs.
[Cell Reports] |
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| To pinpoint mechanisms facilitating the transformation of ABL1-deficient cells, Abl1 was knocked down in 32Dcl3-Abl1ko cells by CRISPR/Cas9 followed by the challenge of growth factor withdrawal.
[Blood Cancer Journal] |
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| Researchers demonstrated that the potential of murine and human HSCs was maintained when cultivated for two days ex vivo at a pH of 6.9, in contrast to cultivation at the commonly used pH of 7.4.
[EMBO Reports] |
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| An Atp8a1 knockout mouse model was employed, from which the long-term and short-term HSC population was analyzed to assess their abundance and function.
[Cellular Oncology] |
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| Investigators demonstrated that the sinusoidal endothelium was an essential and conserved niche component in the zebrafish kidney. Histological analysis revealed that runx1:mCherry+ hematopoietic cells were predominantly detected in the dorsolateral region of the kidney.
[iScience] |
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| Considering the impact of anti-Ad5/HDAd5/35++ neutralizing serum antibodies present in the human population, researchers generated HSC-retargeted HDAd6/35++ vectors derived from serotype 6.
[Molecular Therapy-Methods & Clinical Development] |
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| Scientists reported updated results of a Phase I, open-label, nonrandomized trial, NCT02081378, assessing the safety, tolerability, and antileukemic activity of asciminib monotherapy 10–200 mg once or twice daily in 115 patients with chromosome–positive chronic-phase chronic myeloid leukemia without T315I.
[Leukemia] |
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| The authors discuss recent updates in the classification and risk stratification of AML, explore the literature regarding low-intensity and novel oral combination therapies, and briefly highlight investigative agents currently in early clinical development for high-risk disease subtypes.
[Journal of Hematology & Oncology] |
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| Recent findings have identified novel progenitor subsets of bone marrow adipocytes recruited during bone marrow adipogenesis within different skeletal and HSC niches.
[Stem Cell Reviews and Reports] |
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| Disc Medicine, Inc. announced a collaboration with the National Heart Lung and Blood Institute of the National Institutes of Health to evaluate bitopertin, a therapeutic candidate designed to modulate heme biosynthesis, in a Phase II clinical study of patients with Diamond-Blackfan anemia.
[Disc Medicine, Inc.] |
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| April 17 – 19, 2023
Freiburg im Breisgau, Germany |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | University of Florida – Gainesville, Florida, United States |
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| | Columbia University – New York City, New York, United States |
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| | King’s College London – Strand, England, United Kingdom |
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| | Lund University – Lund, Sweden |
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