 | | Vol. 14.13 – 4 April, 2023 |
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| Using a combination of single-cell multi-omics, lineage tracing, and functional assays, investigators showed that embryonic hematopoietic stem and progenitor cells originate from heterogeneous hemogenic endothelial cells during zebrafish embryogenesis.
[Cell Research] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| | Scientists investigated how exposure to atmospherically relevant artificial particulate matter of diameter less than 2.5 µm affected hematopoietic stem and progenitor cells in newborns. [Journal Of Hazardous Materials] |
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| Investigators observed that the expression of thymocyte-expressed, positive selection-associated 1 (Tespa1) was markedly increased in HSCs after stress exposure.
[Leukemia] |
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| Researchers developed a c-kit antibody-targeted lipid nanoparticle that, following a single intravenous injection, can deliver RNA to HSCs in vivo in rodents.
[Nano Letters] |
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| Scientists showed that loss of Dnmt3a in hematopoietic stem cells and progenitors resulted in myeloproliferation, which was associated with hyperactivation of the PI3Kinase pathway.
[JCI Insight] |
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To analyze the effect of high erythroferron (ERFE) concentrations on hepcidin and iron overload in non-transfusion-dependent β-thalassemia, investigators crossed Th3/+ mice with erythroid ERFE-overexpressing transgenic mice.
[Blood Advances] |
| | Researchers investigated whether autologous HSC transplantation could promote tolerance to heart allografts in mice.
[Clinical & Translational Immunology] |
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| Glucose and 2-deoxy-D-glucose treatment were applied to analyze the relationship between glucose metabolism and cell survival.
[Leukemia Research] |
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| Scientists presented an accurate classification approach to determine the clonal hematopoiesis status from cell-free DNA (cfDNA) sequencing alone, applying their model to 4324 oncology clinical cfDNA samples.
[Science Translational Medicine] |
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| For children undergoing autologous hematopoietic stem cell transplantation for central nervous system tumors, increasing CD34+ cell dose was associated with significantly improved overall survival and progression-free survival without increased non-relapse mortality or endothelial-injury complications.
[Transplantation And Cellular Therapy] |
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| The authors discuss the efficacy and risks of donor lymphocyte infusion, with a focus on pre-emptive and prophylactic use.
[International Journal Of Hematology] |
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| Investigators highlight recent findings focused on Hedgehog signaling in the regulation of hematopoietic development during the early embryonic stage, and the proliferation and differentiation of hematopoietic stem and progenitor cells in adults.
[Molecular Medicine Reports] |
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| Disc Medicine, Inc. announced a collaboration with the National Heart Lung and Blood Institute of the National Institutes of Health to evaluate bitopertin, a therapeutic candidate designed to modulate heme biosynthesis, in a Phase II clinical study of patients with DBA.
[Disc Medicine, Inc.] |
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| April 11 – 12, 2023
New York, New York, United States |
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| | University of Texas Health Science Center – San Antonio, Texas, United States |
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| | University of Birmingham – Birmingham, England, United Kingdom |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | University of Florida – Gainesville, Florida, United States |
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| | King’s College London – Strand, England, United Kingdom |
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