 | | Vol. 14.14 – 11 April, 2023 |
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| Investigators showed that stem state switch involved a global increase in splicing efficiency coordinated by DNA methyltransferase 3α (DNMT3A), an enzyme typically involved in DNA methylation.
[Nature Cell Biology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed that matrix stiffness fine-tunes HSC niche factor expression by bone marrow stromal cells (BMSCs). Increased stiffness activates Yap/Taz signaling to promote BMSC expansion upon 2D culture, which was largely reversed by 3D culture in soft gelatin methacrylate hydrogels.
[Cell Stem Cell] |
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| Base substitution patterns in the single-nucleotide variants suggested a role of reactive oxygen species in radiation mutagenesis, and signature analysis of single base substitutions (SBS) revealed a dose-dependent increase of SBS40.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Using RNAi and a sirtuin 3 (SIRT3) inhibitor (YC8-02), the authors demonstrated that SIRT3 was a critical target for the survival of primary human leukemia stem cells but was not essential for normal human hematopoietic stem and progenitor cell function.
[Haematologica] |
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| Scientists demonstrated that enhancer of zeste homolog 2 (EZH2) regulated human erythropoiesis in a stage-specific, dual-function manner by catalyzing histone and non-histone methylation.
[Haematologica] |
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| Investigators found that the extracellular vesicle (EV) inhibitor Calpeptin, when injected intravenously into mice, particularly affected the in vivo production of EVs carrying phosphorylated Smad2 in mouse bone marrow.
[Cell Death Discovery] |
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| Researchers introduced a general model of hierarchical cell division explaining the particular progression of chronic myeloid leukemia as resulting from the structure of the hematopoietic system.
[Scientific Reports] |
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| Seven cryopreserved cord blood products were thawed, washed, and resuspended in three different solutions,10% Dextran40 in NaCl equally prepared with 5% human albumin; 5% human albumin in phosphate-buffered saline/EDTA, and normal saline, and stored at 4°C.
[Transfusion] |
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| Investigators analyzed cerebral perfusion imaging in boys with cerebral adrenoleukodystrophy treated with autologous HSCs transduced with the Lenti-D lentiviral vector that contained ABCD1 cDNA and patients treated with allogeneic hematopoietic stem cell transplantation.
[Nature Communications] |
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| Scientists demonstrated that AF10 fusion proteins caused aberrant self-renewal via ENL, which bound to MOZ/MORF lysine acetyltransferases. The interaction of ENL with MOZ, via its YEATS domain, was critical for CALM-AF10-mediated leukemic transformation.
[Nature Communications] |
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| The authors describe the functions of HSCs, analyze the regulatory mechanisms that affect their resting state, and discuss the relationship between resting HSCs and different diseases, with a view to providing guidance for the future clinical implementation of related targeted treatments.
[Stem Cell Research & Therapy] |
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| Investigators discuss in detail cell-to-cell interactions in the two leukemic niches, more explored bone marrow, and less studied extramedullary adipose tissue.
[Journal of Leukocyte Biology] |
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| Caribou Biosciences, Inc. announced that the US FDA has granted Fast Track designation to CB-011, which is being developed for relapsed or refractory multiple myeloma (r/r MM). CB-011 is being evaluated in the company’s ongoing CaMMouflage Phase I clinical trial in patients with r/r MM.
[Caribou Biosciences, Inc.] |
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| April 24 – 26, 2023
Hinxton, England, United Kingdom |
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| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | University of Texas Health Science Center – San Antonio, Texas, United States |
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| | University of Birmingham – Birmingham, England, United Kingdom |
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| | Columbia University – New York City, New York, United States |
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| | University of Florida – Gainesville, Florida, United States |
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