Hematopoiesis News Volume 14.15 | Apr 18 2023

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    2023-04-18 | HN 14.15


    Hematopoiesis News by STEMCELL Technologies
    Vol. 14.15 – 18 April, 2023
    TOP STORY

    Clonal Hematopoiesis and Risk of Chronic Liver Disease

    The authors examined the association between clonal hematopoiesis of indeterminate potential and chronic liver disease in 214,563 individuals from four independent cohorts with whole-exome sequencing data.
    [Nature]

    Full Article
    Image of erythroblasts which were simply & efficiently generated from PSCs using the STEMdiff Erythroid Kit.
    PUBLICATIONSRanked by the impact factor of the journal

    DRAG In Situ Barcoding Reveals an Increased Number of HSPCs Contributing to Myelopoiesis with Age

    Investigators presented an in situ single-cell lineage tracing technology to quantify the clonal composition and cell production of single cells in their native niche.
    [Nature Communications]

    Full Article

    High Ploidy Large Cytoplasmic Megakaryocytes Are Hematopoietic Stem Cells Regulators and Essential for Platelet Production

    Scientists showed taht high ploidy large cytoplasmic megakaryocytes are critical negative regulators of HSC and critical for platelet formation.
    [Nature Communications]

    Full Article

    CD150-Dependent Hematopoietic Stem Cell Sensing of Brucella Instructs Myeloid Commitment

    By using specific genetic tools, researchers showed that HSC could directly sense B. abortus pathogenic bacteria within the bone marrow via the interaction of the cell surface protein CD150 with the bacterial outer membrane protein Omp25, inducing efficient functional commitment of HSC to the myeloid lineage.
    [Journal Of Experimental Medicine]

    Abstract

    The Zinc Transporter SLC39A10 Plays an Essential Role in Embryonic Hematopoiesis

    Using both zebrafish and mouse models, scientists found that HSCs require SLC39A10 for survival, and provided compelling evidence that SLC39A10 is the master regulator of zinc upregulation in HSCs during early hematopoiesis.
    [Advanced Science]

    Abstract

    Gene Therapy Restores the Transcriptional Program of Hematopoietic Stem Cells in Fanconi Anemia

    Investigators demonstrated that gene therapy reverted the transcriptional signature of Fanconi anemia hematopoietic stem and progenitor cells (HSPCs), which then resembles the transcriptional program of healthy donor HSPCs.
    [Haematologica]

    Abstract

    Maternal Diet Alters Long-Term Innate Immune Cell Memory in Fetal and Juvenile Hematopoietic Stem and Progenitor Cells in Nonhuman Primate Offspring

    Using nonhuman primate models, researchers showed that maternal Western-style diet exposure was associated with persistent pro-inflammatory phenotypes at the transcriptional, metabolic, and functional levels in bone marrow-derived macrophages.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Modelling the Erythroblastic Island Niche of Dyserythropoietic Anemia Type IV Patients Using Induced Pluripotent Stem Cells

    Investigators showed data that supported the notion that the clinically significant effects of the KLF1-E325K mutation were primarily associated with deficiencies in the erythroid lineage but it is possible that deficiencies in the niche might have the potential to exacerbate the condition.
    [Frontiers In Cell And Developmental Biology]

    Full Article

    A Novel Integrative Multi-Omics Approach to Unravel the Genetic Determinants of Rare Diseases with Application in Sinusoidal Obstruction Syndrome

    Scientists classified 315 newly diagnosed AML patients at their center based on the expression of CD11b and CD64. The CD11b+CD64+ populations were identified as independent risk factors for overall survival and event-free survival of AML, exhibiting specific clinicopathological features.
    [Cellular Oncology]

    Abstract
    Learn how to optimize genome editing conditions for CD34+ cells, evaluate genome editing efficiency, and much more!
    REVIEWS

    In Vitro Simulation of the Acute Lymphoblastic Leukemia Niche: A Critical View on the Optimal Approximation for Drug Testing

    Researchers discuss in detail cell-to-cell interactions in the two leukemic niches, more explored bone marrow (BM), and less studied extramedullary adipose tissue (EMAT). Emphasis was given to multiple ways of interactions of acute lymphoblastic leukemia (ALL) cells with BM or EMAT microenvironment.
    [Journal Of Leukocyte Biology]

    Abstract
    Graphical Abstract
    INDUSTRY AND POLICY NEWS

    FDA Fast Tracks CB-011 for Relapsed/Refractory Multiple Myeloma

    The FDA granted a fast track designation to CB-011, a CRISPR-edited allogeneic CAR T-cell therapy developed by Caribou Biosciences, for the treatment of patients with relapsed/refractory multiple myeloma.
    [OncLive]

    Press Release

    Layoffs Loom as Takeda Trims Early-Stage Efforts in AAV Gene Therapy, Rare Hematology

    Takeda has moved away from early-stage R&D work in adeno-associated virus-based gene therapies and the rare hematology spaces, with an unknown number of employees set to “transition out” of the pharma.
    [Fierce Biotech]

    Press Release
    FEATURED EVENT

    World Oncology Cell Therapy Congress

    April 25 – 26, 2023
    Boston, Massachusetts, United States

    > See All Events

    JOB OPPORTUNITIES

    Research Technician – iPSC Model for Hematopoiesis

    Sanquin Blood Supply – Amsterdam, Netherlands

    Faculty Positions – Cancer Research

    Case Western Reserve University – Cleveland, Ohio, United States

    Postdoctoral Fellow – Leukemia Research

    University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    Postdoctoral Position – Cancer Metabolism, Epigenetics, Hematopoiesis

    University of Texas Health Science Center – San Antonio, Texas, United States

    PhD Project – Biomimetic ECM Coatings

    University of Birmingham – Birmingham, England, United Kingdom

    > See All Jobs

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