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Vol. 14.16 – 25 April, 2023
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This Phase III study was designed to compare the safety and efficacy of motixafortide + granulocyte colony-stimulating factor (G-CSF) versus placebo + G-CSF in patients with multiple myeloma undergoing hematopoietic stem progenitor cell mobilization before autologous hematopoietic stem cell transplantation.
[Nature Medicine]
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PUBLICATIONSRanked by the impact factor of the journal
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Investigators showed that obesity was highly associated with CHIP and that a pro-inflammatory state could potentiate the progression of CHIP to more significant hematologic neoplasia.
[Journal Of Clinical Investigation]
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Researchers examined immune responses in genetically distinct models of AML and demonstrated that specific AML oncogenes dictate immunogenicity, the quality of immune response, and immune escape through immunoediting.
[Nature Communications]
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Scientists showed that AML-derived macrophages presented immunosuppressive and pro-leukemogenic functions, in part related to the acquisition of AML mutations.
[Science Advances]
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Investigators reported pre-clinical single-agent activity of 753B against different leukemia subsets. 753B effectively reduced cell viability and induced dose-dependent degradation of BCL-XL and BCL-2 in a subset of hematopoietic cell lines, AML primary samples, and in vivo PDX AML model.
[Haematologica]
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Researchers tested whether reticulocytes in donor RBC units could enhance RBC alloimmunization. Using a murine model, they demonstrated that transfusing donor RBC units with increased reticulocyte frequencies dose-dependently increased RBC alloimmunization rates and alloantibody levels.
[Haematologica]
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Investigators characterized and quantified fetal megakaryocytic cells in mouse fetal liver according to their glycan residues at different gestational ages through lectins.
[Scientific Reports]
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Researchers provided insights into the transcriptomic features of TMEM173 in the bone marrow of high-risk B cell acute lymphoblastic leukemia (B-ALL) patients. Targeted activation of TMEM173 in specific cells might provided new therapeutic strategies for B-ALL patients.
[BMC Cancer]
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Scientists reported the results of a retrospective analysis on second allogeneic transplantation treated with total marrow irradiation as a myeloablative conditioning regimen, intending to limit toxicity.
[Transplantation And Cellular Therapy]
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The authors update knowledge regarding the diagnosis and severity assessment of sinusoidal obstruction syndrome, also known as veno-occlusive disease in adult patients, and also its pathophysiology and treatment.
[Bone Marrow Transplantation]
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ALX Oncology Holdings Inc. announced it has entered into a clinical trial collaboration and supply agreement with Sanofi to evaluate the combination of Evorpacept, a CD47 blocker, and SARCLISA, for the treatment of patients with relapsed or refractory multiple myeloma.
[ALX Oncology Holdings, Inc.]
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University of Texas Health Science Center – San Antonio, Texas, United States
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University Medical Center Groningen – Groningen, Netherlands
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University of Reading – Reading, England, United Kingdom
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Sanquin Blood Supply – Amsterdam, Netherlands
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Case Western Reserve University – Cleveland, Ohio, United States
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