Hematopoiesis News Volume 14.17 | May 02 2023

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    2023-05-02 | HN 14.17


    Hematopoiesis News by STEMCELL Technologies
    Vol. 14.17 – 2 May, 2023
    TOP STORY

    The Transcriptional and Regulatory Identity of Erythropoietin Producing Cells

    Researchers performed single-cell RNA and transposase-accessible chromatin sequencing of an erythropoietin reporter mouse to molecularly identify erythropoietin-producing cells under hypoxic conditions.
    [Nature Medicine]

    AbstractPress Release
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    Clonally Resolved Single-Cell Multi-Omics Identifies Routes of Cellular Differentiation in Acute Myeloid Leukemia

    Scientists introduced CloneTracer, a novel method that adds clonal resolution to single-cell RNA-seq datasets. Applied to samples from 19 AML patients, CloneTracer revealed routes of leukemic differentiation.
    [Cell Stem Cell]

    Full ArticlePress ReleaseGraphical Abstract

    Targeting DNA Polymerase β Elicits Synthetic Lethality With Mismatch Repair Deficiency in Acute Lymphoblastic Leukemia

    Investigators provided evidence that DNA polymerase β of base excision repair pathway plays a critical role in the survival and thiopurine resistance of mismatch pari-deficient acute lymphoblastic leukemia cells.
    [Leukemia]

    Abstract

    Transcription Factor Nkx2-3 Maintains the Self-Renewal of Hematopoietic Stem Cells by Regulating Mitophagy

    Scientists showed that the homeobox transcription factor Nkx2-3 was required for HSC self-renewal by preserving metabolic fitness. They found that Nkx2-3 was preferentially expressed in HSCs with excessive regenerative potential.
    [Leukemia]

    Abstract

    A Mechanosensitive Vascular Niche for Drosophila Hematopoiesis

    Researchers discovered that the mechanosensing of blood flow by vascular niche cells regulated hematopoietic progenitor maintenance in the Drosophila hematopoietic organ. Furthermore, they identified molecular processes involved from mechanosensing to mechanotransduction.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract

    BCR-ABL Triggers a Glucose-Dependent Survival Program During Leukemogenesis Through the Suppression of TXNIP

    Scientists demonstrated that thioredoxin-interacting protein (TXNIP) was a novel BCR-ABL target gene. Suppression of TXNIP was responsible for BCR-ABL triggered glucose metabolic reprogramming and mitochondrial homeostasis.
    [Cell Death & Disease]

    Full Article

    In Vitro Erythrocyte Production Using Human-Induced Pluripotent Stem Cells: Determining the Best Hematopoietic Stem Cell Sources

    Human-induced pluripotent stem cells were established from three different HSC sources—peripheral blood, cord blood, and bone marrow aspirates —using episomal reprogramming vectors and differentiated into functionalred blood cells.
    [Stem Cell Research & Therapy]

    Full Article

    Efficacy and Safety of Allogeneic Hematopoietic Cell Transplantation in Acute Myeloid Leukemia Patients Aged > 65 Years With Unfavorable Cytogenetics

    Investigators identified factors associated with the outcomes of unrelated donor (UR) bone marrow transplantation, UR-cord blood stem cell transplantation, and haploidentical peripheral blood stem cell transplantation in older patients with AML.
    [Annals Of Hematology]

    Abstract

    Longitudinal Relationship Between the Gut Microbiota Variation and Diversity and Gut Graft-Versus-Host Disease (GVHD) Following Pediatric Allogeneic Hematopoietic Cell Transplantation (HCT) – Case Series

    Scientists conducted a prospective, longitudinal cohort study in nine pediatric allogeneic hematopoietic cell transplantation (HCT) participants by collecting longitudinally post-HCT stool specimens for up to 1 year.
    [International Journal Of Medical Microbiology]

    Full Article
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    REVIEWS

    Management of Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia in the Current Era

    The authors highlight the evolving treatment landscape of Philadelphia chromosome-positive acute lymphoblastic leukemia and what to look for in the future.
    [Current Research In Translational Medicine]

    Abstract
    INDUSTRY AND POLICY NEWS

    Editas Medicine Receives FDA Orphan Drug Designation For EDIT-301 For The Treatment Of Sickle Cell Disease

    Editas Medicine, Inc. announced that the US FDA granted Orphan Drug Designation to EDIT-301, an investigational, gene-editing medicine, for the treatment of sickle cell disease.
    [Editas Medicine, Inc.]

    Press Release
    FEATURED EVENT

    The Resistant Tumor Microenvironment

    May 7 – 10, 2023
    Vancouver, British Columbia, Canada

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Cellular and Molecular Therapeutics

    National Institutes of Health – Bethesda, Maryland, United States

    Postdoctoral Research Associate – Oncology

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    Postdoctoral Position – Cancer Metabolism, Epigenetics, and Hematopoiesis Research

    University of Texas Health Science Center – San Antonio, Texas, United States

    PhD Positions – Macrophage Landscape in AML

    University Medical Center Groningen – Groningen, Netherlands

    Postdoctoral Studentship – Platelet Function in Liver Disease

    University of Reading – Reading, England, United Kingdom

    > See All Jobs

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