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| Scientists designed improved leukemia immunotherapy approaches, comprehensively identified non-coding variants modulating fetal hemoglobin expression, defined mechanisms regulating hematopoietic differentiation, and probed the pathogenicity of uncharacterized disease-associated variants.
[Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers reported that PIWIL4 was overexpressed in AML patients and was essential for leukemic stem cell function and AML growth, but dispensable for healthy human hematopoietic stem cells.
[Blood] |
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| Through the use of single-cell analysis and transplantation assays, investigators provided evidence of Jagged1 as a novel niche factor for fetal liver HSCs.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Scientists analyzed the clinical characteristics of ASXL1 mutations in myelofibrosis patients and generated hematopoietic-specific Asxl1 knockout and Jak2V617F knock-in mouse models.
[Haematologica] |
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| Researchers revealed a brand-new aspect of gmfg function and highlighted a novel mechanism for embryonic hematopoietic stem and progenitor cell development.
[Stem Cell Research & Therapy] |
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| Investigators uncovered the intrinsic and microenvironmental mechanisms of interleukin 34 (IL-34) in AML and broadened the knowledge of macrophage colony-stimulating factor (CSF)/IL-34-CSF-1R axis in malignancies.
[Cell Death & Disease] |
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| Scientists underscored the important role of smooth muscle and endothelial cell‐enriched migration/differentiation‐associated lncRNA in regulating the malignant phenotype of AML cells by targeting the miR-4731–5p/IRF2 axis.
[Pathology – Research and Practice] |
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| | Researchers retrospectively analyzed the outcomes of 355 adult patients with B cell acute lymphoblastic leukemia in first complete remission who had received auto-HSCT or allogeneic HSCT in their centre.
[British Journal Of Haematology] |
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| This observational retrospective single-center study reported the efficacy and safety of the BeEAM regimen. 55 patients with diffuse large B cell lymphoma, Hodgkin lymphoma, mantle cell lymphoma, or follicular lymphoma were included.
[Leukemia & Lymphoma] |
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The authors summarize the recent findings on long non-coding RNA-mediated regulation of therapeutic resistance in leukemia and discuss future perspectives on how to make use of the dysregulated lncRNAs in leukemia to improve treatment outcomes.
[Cancer Medicine] |
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| The Icahn School of Medicine at Mount Sinai announced the creation of the Institute for Regenerative Medicine to foster innovative research into new pathways to cure a host of diseases from leukemia to Alzheimer’s disease, breast cancer, and airway diseases.
[Mount Sinai Hospital] |
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| May 23 – 25, 2023
Bar Harbor, Maine, United States & Virtual |
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| | University of Texas Health Science Centre – San Antonio, Texas, United States |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| | National Institutes of Health – Bethesda, Maryland, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | University of Texas Health Science Center – San Antonio, Texas, United States |
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