 | | Vol. 14.19 – 16 May, 2023 |
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| Investigators reported in vitro and in vivo testing of the activity of a novel Cereblon modulator, SJ6986, in a panel of acute lymphoblastic leukemia cell lines and xenografts.
[Blood] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed for the first time that BCR::ABL1 drove the cytokine independent expansion of bone marrow derived mast cells and sensitized them for FcεRI triggered degranulation.
[Leukemia] |
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| Through the use of single-cell analysis and transplantation assays, investigators provided evidence of Jagged1 as a novel niche factor for fetal liver HSCs.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| The authors observed that the expression of pseudouridine (Ψ) synthase 10 was increased in aged hematopoietic stem and progenitor cells, and enforced PUS10 recapitulated the phenotype of aged hematopoietic stem cells, which was not achieved by its Ψ synthase activity.
[Haematologica] |
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| Researchers showed that the AML-specific autocrine loop comprised of T-cell immunoglobulin mucin-3 (TIM-3) and its ligand, galectin-9, drove the canonical Wnt pathway to stimulate self-renewal and propagation of leukemic stem cells, independent of Wnt ligands.
[Blood Advances] |
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| Scientists engineered a knock-in mouse line with conditional expression of PHD finger protein 6 (Phf6)R274X mutated protein in the hematopoietic system.
[iScience] |
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| The authors identified protein arginine methyltransferase 1 (PRMT1) as a ferroptosis regulator in AML. The type I PRMT inhibitor GSK3368715 promoted ferroptosis sensitivity in vitro and in vivo.
[Molecular Carcinogenesis] |
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| Investigators identified a short, conserved enhancer element in Erythroid Krüppel-like Factor (KLF1) intron 1 that was important for establishing optimal levels of KLF1 in mouse and human cells.
[Scientific Reports] |
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| Scientists retrospectively analyzed a German cohort of 488 pediatric patients with de novo AML, enrolled in the AMLR12 or AMLR17 registry of the AML-BFM Study Group. A total of 23 pediatric AML patients harbored runt-related transcription factor-1 (RUNX1) mutations.
[Leukemia] |
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| Twenty adult patients undergoing hematopoietic stem cell transplantation for acute lymphoblastic leukemia and chronic myeloid leukemia with lymphoid blast crises received total marrow lymphoid irradiation and cyclophosphamide for conditioning.
[Clinical Transplantation] |
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| The authors review the features of HSCs, and the effects of viral infections on HSCs and HSC transplantation, such as SARS-CoV-2, HIV, cytomegalovirus, Epstein-Barr virus, HIV, etc.
[Cell Communication and Signaling] |
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| Scientists describe the various functions of snoRNAs, their role in hematopoiesis, and the consequences of their dysregulation in blood malignancies.
[Journal of Cellular Physiology] |
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| Investigators discuss the coordinated effects of the purinergic signaling pathways and the complement cascade in regulating the biology of hematopoietic stem/progenitor cells.
[Purinergic Signalling] |
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| NYBC Ventures announced the launch of its inaugural fund with a $50 million investment from New York Blood Center, Inc. (NYBC) to accelerate innovation in blood-related fields, cellular therapies, and enabling technologies.
[NYBC Ventures (Business Wire)] |
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| June 2 – 6, 2023
Chicago, Illinois, United States |
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| | Fox Chase Cancer Center – Philadelphia, Pennsylvania, United States |
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| | Centre for Oncology and Immunology – Hong Kong |
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| | University of Texas Health Science Centre – San Antonio, Texas, United States |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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