Hematopoiesis News Volume 14.20 | May 23 2023

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    Noshin Noorjahan
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    2023-05-23 | HN 14.20


    Hematopoiesis News by STEMCELL Technologies
    Vol. 14.20 – 23 May, 2023
    TOP STORY

    Regeneration after Blood Loss and Acute Inflammation Proceeds without Contribution of Primitive HSCs

    To investigate the contribution of primitive HSCs to the hematopoietic stress response in the native environment, the authors used fate mapping and proliferation tracking mouse models.
    [Blood]

    Abstract
    The StemSpan™ T Cell Generation Kit is designed to promote differentiation of HSPCs into T cells in stroma- and serum-free culture conditions.
    PUBLICATIONSRanked by the impact factor of the journal

    Microenvironmental Control of Hematopoietic Stem Cell Fate via CXCL8 and Protein Kinase C

    Genetically barcoded genome editing of synthetic target arrays for lineage tracing zebrafish were used to screen for factors expressed by the sinusoidal vascular niche that altered the phylogenetic distribution of the HSC pool under native conditions.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Repression of TRIM13 by Chromatin Assembly Factor CHAF1B Is Critical for AML Development

    Scientists analyzed RNAseq from mouse MLL-AF9 leukemic cells and bone marrow aspirates representing a diverse collection of pediatric AML samples and identified the E3 ubiquitin ligase TRIM13 as a target of CHAF1B-mediated transcriptional repression associated with leukemogenesis.
    [Blood Advances]

    Abstract

    GPAM Mediated Lysophosphatidic Acid Synthesis Regulates Mitochondrial Dynamics in Acute Myeloid Leukemia

    Through the metabolite screening comparing CD34+ AML cells and healthy hematopoietic stem/progenitor cells, investigators identified enhanced lysophosphatidic acid synthesis activity in AML.
    [Cancer Science]

    Full Article

    Gene SH3BGRL3 Regulates Acute Myeloid Leukemia Progression through circRNA_0010984 Based on Competitive Endogenous RNA Mechanism

    Scientists detected the expression of SH3BGRL3 and circRNA_0010984 among genes with protein-coding function obtained from the TCGA database by qRT-PCR. They synthesized plasmid vectors and carried out cell experiments, including cell proliferation, cell cycle, and cell differentiation by cell transfection.
    [Frontiers in Cell and Developmental Biology]

    Abstract

    Modulation of WNT, Activin/Nodal, and MAPK Signaling Pathways Increases Arterial Hemogenic Endothelium and Hematopoietic Stem/Progenitor Cell Formation during Human iPSC Differentiation

    Researchers modulated WNT, Activin/Nodal, and MAPK signaling pathways by stage-specific addition of small molecule regulators CHIR99021, SB431542, and LY294002, respectively, and measured the impact on hematoendothelial formation in culture.
    [Stem Cells]

    AbstractGraphical Abstract

    Pinostrobin, a Fingerroot Compound, Regulates miR-181b-5p and Induces Acute Leukemic Cell Apoptosis

    The authors investigated the effects of pinostrobin (PN) on proliferation inhibition and induction of apoptosis, as well as the involvement of miRNAs in PN-mediated apoptosis in acute leukemia.
    [Scientific Reports]

    Full Article

    Increased MYB Alternative Promoter Usage Is Associated with Relapse in Acute Lymphoblastic Leukemia

    Investigators used RNA-seq to study the clinical significance of MYB expression and MYB alternative promoter (TSS2) usage in 133 pediatric acute lymphoblastic leukemia. RNA-seq revealed that all cases analyzed overexpressed MYB and demonstrated MYB TSS2 activity.
    [Genes Chromosomes & Cancer]

    Full Article

    Prevalence and Clinical Expression of Germline Predisposition to Myeloid Neoplasms in Adults with Marrow Hypocellularity

    Scientists performed germline and somatic targeted sequencing in a large cohort of adult patients with cytopenia and hypoplastic bone marrow to study germline predisposition variants and their clinical correlates.
    [Blood]

    Abstract

    Prognostic Impact of Complex and/or Monosomal Karyotypes in Post-Transplant Poor Cytogenetic Acute Myeloid Leukemia: A Quantitative Approach

    To evaluate the prognostic impact of complex karyotype and/or monosomal karyotype on allogeneic stem cell transplantation (HSCT) outcomes of patients with AML, researchers analyzed the registry database of adult AML patients who underwent allogeneic HSCT between 2000 and 2019 in Japan.
    [British Journal of Haematology]

    Full Article
    Watch the webinar where Dr. Suzan Imren discusses factors affecting the balance between HSC self-renewal and leukemic transformation
    REVIEWS

    Telomerase-Targeted Therapies in Myeloid Malignancies

    The authors summarize telomere and telomerase biology as it relates to both physiologic and malignant cells. They discuss the development of telomere and telomerase targeted therapeutic candidates within the realm of myeloid malignancies.
    [Blood Advances]

    Abstract

    The Role of m6A mRNA Modification in Normal and Malignant Hematopoiesis

    Investigators focus on recent progress in identifying the biological functions of m6A mRNA modification, its regulators, and downstream gene targets during normal and pathological hematopoiesis.
    [Journal of Leukocyte Biology]

    AbstractGraphical Abstract

    Research Progress on the Hematopoietic Microenvironment in Aplastic Anemia

    Scientists summarize the research on the hematopoietic microenvironment of aplastic anemia (AA) in recent years to provide new ideas for the clinical treatment of AA.
    [European Journal of Haematology]

    Full Article
    INDUSTRY AND POLICY NEWS

    MD Anderson Awarded over $5.7 Million from Break through Cancer to Support AML Research

    The University of Texas MD Anderson Cancer Center was awarded more than $5.7 million in grants from Break Through Cancer to support collaborative research teams working to discover novel molecular targets to eradicate minimal residual disease in AML and to treat clonal hematopoiesis.
    [The University of Texas MD Anderson Cancer Center]

    Press Release
    FEATURED EVENT

    The 2023 ASCO Annual Meeting

    June 2 – 6, 2023
    Chicago, Illinois, United States

    > See All Events

    JOB OPPORTUNITIES

    Research Assistant – Leukemia

    University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    Postdoctoral Fellowship – Biomolecular Spectroscopy

    The University of British Columbia – Vancouver, British Columbia, Canada

    Research Technician – Leukemia

    Fox Chase Cancer Center – Philadelphia, Pennsylvania, United States

    Postdoctoral Fellow – Oncology and Immunology

    Centre for Oncology and Immunology – Hong Kong, Hong Kong

    Postdoctoral Position – Epigenetic Regulation in Normal and Malignant Hematopoiesis

    University of Texas Health Science Centre – San Antonio, Texas, United States

    > See All Jobs

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