 | | Vol. 14.21 – 30 May, 2023 |
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| Scientists presented the development of a potent inhibitor of deoxycytidine kinase by applying an iterative multidisciplinary approach, which relied on computational design coupled with experimental evaluations.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed that disabling HSCs based on disrupting autophagy accelerated niche aging in mice, whereas transplantation of young, but not aged or impaired, donor HSCs normalized niche cell populations and restored niche factors in host mice carrying an artificially harassed niche.
[Aging Cell] |
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| Cd36 knockout mice were evaluated for blood analysis, hematopoietic stem cells and progenitors function and phenotype analyses, and T cells in vitro expansion and phenotypes in comparison with wild-type mice.
[Cellular & Molecular Biology Letters] |
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| Investigators profiled the spectrum of Fms-like tyrosine kinase 3 (FLT3) mutations in 869 consecutively newly diagnosed AML, myelodysplastic syndrome, and acute lymphoblastic leukemia patients.
[British Journal of Haematology] |
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| Researchers presented an integrated short- and long-read single-cell RNA-seq analysis of hematopoietic stem and progenitor cells. They demonstrated that over half of genes detected in standard short-read single-cell analyses were expressed as multiple, often functionally distinct, isoforms.
[Communications Biology] |
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| Scientists presented a high-resolution characterisation of the bone marrow (BM) niche in health and AML by establishing a single-cell gene expression database of 339,381 BM cells.
[iScience] |
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| The authors analyzed the expression of DHX9 and its clinical significance in 120 myelodysplastic syndrome (MDS) patients and 42 non-MDS controls. Lentivirus-mediated DHX9 knockdown experiments were performed to investigate its biological function.
[iScience] |
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| Investigators presented an unplanned exploratory analysis evaluating the hematopoietic reconstitution kinetics, engraftment, and clonality in 13 pediatric Wiskott-Aldrich syndrome patients treated with autologous lentiviral-vector transduced hematopoietic stem/progenitor cells.
[Nature Communications] |
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| Three metachromatic leukodystrophy patients treated with hematopoietic stem cell transplantation with a progressive clinical course despite stable white matter pathology were clinically and radiologically analyzed.
[Annals Of Clinical And Translational Neurology] |
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| Scientists review the clinical manifestations of GATA2 deficiency, characterization of the hematologic abnormalities and progression to myeloid malignancy, and current hematopoietic cell transplantation practices and outcomes.
[Current Hematologic Malignancy Reports] |
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| The US National Institutes of Health (NIH) delivered a stern warning to two in-house clinical researchers who had broken an important rule. They had failed to submit the results of two clinical trials they had overseen to ClinicalTrials.gov, a database meant to inform the public about human studies and their results.
[Science] |
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| June 13 – 17, 2023
Lugano, Switzerland |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | Fox Chase Cancer Center – Philadelphia, Pennsylvania, United States |
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| | Centre for Oncology and Immunology – Hong Kong, Hong Kong |
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| | University of Texas Health Science Centre – San Antonio, Texas, United States |
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