Hematopoiesis News Volume 14.22 | June 06 2023

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    Noshin Noorjahan
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    2023-06-06 | HN 14.22


    Hematopoiesis News by STEMCELL Technologies
    Vol. 14.22 – 6 June, 2023
    TOP STORY

    Loss of TET2 in Human Hematopoietic Stem Cells Alters the Development and Function of Neutrophils

    Using genetic engineering of human HSCs and transplantation in immunodeficient mice, scientists described how a commonly mutated gene in clonal hematopoiesis, TET2, affected human neutrophil development and function.
    [Cell Stem Cell]

    Full ArticleGraphical Abstract
    Guide to everything you need to know about cell separation.
    PUBLICATIONSRanked by the impact factor of the journal

    Inhibition of FGF23 Is a Therapeutic Strategy to Target Hematopoietic Stem Cell Niche Defects in β-Thalassemia

    Researchers demonstrated that fibroblast growth factor 23 (FGF23) was increased in patients and mice with β-thalassemia because erythropoietin induced FGF23 overproduction in bone and bone marrow erythroid cells via ERK1/2 and STAT5 pathways.
    [Science Translational Medicine]

    Full Article

    Mitochondrial Pyruvate Metabolism and Glutaminolysis Toggle Steady-State and Emergency Myelopoiesis

    To define the metabolic requirements of hematopoiesis, investigators examined blood lineages in mice conditionally deficient in genes required for long-chain fatty acid oxidation, glutaminolysis, or mitochondrial pyruvate import.
    [Journal of Experimental Medicine]

    Full Article

    Both Maternal IFNγ Exposure and Acute Prenatal Infection with Toxoplasma gondii Activate Fetal Hematopoietic Stem Cells

    The authors investigated the fetal hematopoietic response to maternal infection with Toxoplasma gondii, an intracellular parasite that elicited Type II IFNγ-mediated maternal immunity.
    [EMBO Journal]

    Full ArticleGraphical Abstract

    Lineage Skewing and Genome Instability Underlie Marrow Failure in a Zebrafish Model of GATA2 Deficiency

    Single-cell transcriptomics and chromatin accessibility assays revealed that loss of gata2a led to skewing toward the erythroid lineage at the expense of myeloid cells, associated with loss of cebpa expression and decreased PU.1 and CEBPA transcription factor accessibility in hematopoietic stem and progenitor cells.
    [Cell Reports]

    Full ArticleGraphical Abstract

    EIF4A3-Induced Circ_0001187 Facilitates AML Suppression through Promoting Ubiquitin-Proteasomal Degradation of METTL3 and Decreasing m6A Modification Level Mediated by miR-499a-5p/RNF113A Pathway

    Researchers identified a novel circRNA, Circ_0001187, which was downregulated in AML patients, and its low level contributes to a poor prognosis.
    [Biomarker Research]

    Full Article

    Circadian Clock Protein Bmal1 Accelerates Acute Myeloid Leukemia by Inhibiting Ferroptosis through the EBF3/ALOX15 Axis

    Investigators reported elevated brain and muscle ARNT-Like protein-1 (Bmal1) expression in AML patients and cell lines, and its upregulation indicated the poor survival of patients.
    [Cancer Science]

    Full Article

    Leukemia Relapse via Genetic Immune Escape after Allogeneic Hematopoietic Cell Transplantation

    Through a broad immunogenetic study, scientists demonstrated that germline and somatic reduction of human leucocyte antigen heterogeneity enhanced the risk of leukemic recurrence.
    [Nature Communications]

    Full Article

    Unrelated or Haploidentical Allogeneic Hematopoietic Cell Transplantation in Second Complete Remission for Acute Myeloid Leukemia—Improved Outcomes Over Time: A European Society for Blood and Marrow Transplantation Acute Leukemia Working Party Study

    Even in the absence of a matched sibling donor, outcomes of allogeneic hematopoietic cell transplantation in second complete remission for acute myeloid leukemia have significantly improved over time, with the most favorable outcomes achieved with matched unrelated donors.
    [Cancer]

    Abstract
    Watch this webinar to learn the advantages of using primary human nasal epithelial cells to study Cystic Fibrosis.
    REVIEWS

    Targeting Integrins in Drug Resistant Acute Myeloid Leukemia

    The authors focus on the bone marrow microenvironment and review the role of integrins in cell-adhesion mediated drug-resistance of AML and in integrin targeting strategies.
    [British Journal of Pharmacology]

    Abstract

    The Tip of the Iceberg—The Roles of Long Noncoding RNAs in Acute Myeloid Leukemia

    Scientists assess the key studies which have recently identified lncRNAs as important molecules in AML and summarize the current knowledge of lncRNAs in AML.
    [WIREs RNA]

    Full ArticleGraphical Abstract
    INDUSTRY AND POLICY NEWS

    FDA Oncology Head Wants Advisory Panels to Keep Voting on New Drugs

    As commissioner of the FDA, Robert Califf has made clear he would like to do away with the votes that punctuate meetings of expert panels evaluating new drugs for approval.
    [STAT News]

    Press Release
    FEATURED EVENT

    Single Cell Biology: From Development to Cancer

    June 18 – 22, 2023
    Keystone, Colorado, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Life Science Research

    Human Technopole – Milan, Italy

    Technician – Life Science Research

    Human Technopole – Milan, Italy

    Postdoctoral Research Associate – Bioinformatics & Umbilical Cord Blood

    University of Edinburgh – Edinburgh, Scotland, United Kingdom

    Postdoctoral Fellowship – Biomolecular Spectroscopy

    The University of British Columbia – Vancouver, British Columbia, Canada

    Research Technician – Leukemia

    Fox Chase Cancer Center – Philadelphia, Pennsylvania, United States

    > See All Jobs

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