 | | Vol. 14.23 – 13 June, 2023 |
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| Researchers showed that circular RNAs (circRNAs)—a family of covalently closed, alternatively spliced RNA molecules—were enriched within the mixed lineage leukemia (MLL) recombinome and could bind DNA, forming circRNA:DNA hybrids at their cognate loci.
[Cancer Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists demonstrated that transplantation of fetal HSCs made vitamin D deficient in utero induce diabetes in vitamin D-sufficient mice.
[Nature Communications] |
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| Researchers identified microRNA (miR)-223 as a negative regulator of murine hemogenic endothelial cell specification and endothelial-to-hematopoietic transition.
[Developmental Cell] |
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| Investigators showed that interleukin-6 (IL-6) receptor antibody treatment reversed the atherosclerosis promoted by Tet2 clonal hematopoiesis, with reduction of monocytosis, lesional macrophage burden, and macrophage colony-stimulating factor 1 receptor expression.
[Nature Cardiovascular Research] |
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| Scientists demonstrated that human lymphopoiesis was supported by three waves of embryonic, fetal, and postnatal multi-lymphoid progenitors differing in CD7 and CD10 expression and their output of CD127−/+ early lymphoid progenitors.
[Cell Reports] |
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| To systematically dissect the unique physiology and uncover susceptibilities that can be exploited in near-haploid leukemia, the authors leveraged single-cell RNA-Seq and computational inference of cell cycle stages to pinpoint key differences between near-haploid and diploid leukemia cells.
[Blood Cancer Journal] |
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| Researchers investigated the impact of NUP98-KDM5A expression on cellular processes in human pluripotent stem cell models and a patient-derived cell line.
[Cell Death & Disease] |
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| Investigators characterized hematopoiesis at several different stages of blood formation, from HSCs to mature blood cells, and found that loss of the IFN-1 receptor led to depletion of several phenotypic HSC and multipotent progenitors subpopulations in neonatal and juvenile mice.
[Blood Advances] |
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| By using Runx1F/FMx1-Cre mouse model, scientists discovered that the megakaryocyte (MK)-HSC to MK direct differentiation could occur within 1 cell division, and RUNX1 was an important regulator in the process.
[Blood Advances] |
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| The authors demonstrated that WNT5A protein upregulated the WNT non-canonical pathway only in leukemic cells, without modulating normal cell behavior.
[Journal of Cell Communication and Signaling] |
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| Investigators took advantage of a large international multicenter cohort to evaluate the role of TP53MT in patients with myelofibrosis undergoing HSC transplantation.
[Blood] |
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| Researchers reported that mice with germline monoallelic deletion or induced biallelic deletion of the 9p21-syntenic locus developed a fatal myelodysplastic syndrome/myeloproliferative neoplasm-like disease associated with aberrant trabecular bone formation and/or fibrosis in the bone marrow.
[Blood] |
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| The authors delve into the intricacies of clonal evolution in myeloid malignancies and its implications for the development of new diagnostic and therapeutic approaches.
[Trends in Cancer] |
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| Scientists focus on the reciprocal interactions between leukemia stem cells and their milieu in the bone marrow.
[British Journal of Pharmacology] |
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| Chinese scientists say they have conducted a first-of-its-kind experiment to produce blood stem cells in space. The stem cells were brought back to Earth by the Shenzhou 15 spacecraft after being cultured for half a month in the Wentian lab module of China’s Tiangong space station.
[South China Morning Post] |
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| June 28 – 30, 2023
Kyoto, Japan |
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| | University of Michigan – Ann Arbor, Michigan, United States |
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| | The University of New South Wales – Sydney, Australia |
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| | Human Technopole – Milan, Italy |
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| | Human Technopole – Milan, Italy |
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| | University of Edinburgh – Edinburgh, Scotland, United Kingdom |
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