 | | Vol. 14.24 – 20 June, 2023 |
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| Researchers uncovered three transcriptomic subtypes of BCR-ABL1 lymphoblastic leukemia, each representing a maturation arrest at a stage of B-cell progenitor differentiation. An earlier arrest was associated with lineage promiscuity, treatment refractoriness, and poor patient outcomes.
[Nature Genetics] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators reported that defective ribonucleotide excision repair in the hematopoietic system caused genome instability with concomitant activation of the cGAS/STING axis and compromised hematopoietic stem cell function, ultimately resulting in leukemogenesis.
[Cancer Research] |
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| Scientists investigated morphological and mechanical characteristics of red blood cells (RBCs) after SARS-CoV-2 infection in children and adolescents by real-time deformability-cytometry, to investigate the relationship between alterations of RBCs and clinical course of COVID-19.
[Scientific Reports] |
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| iPSC derived macrophage and dendritic like cells were compared to CD34+ haematopoietic stem cell derived populations using transcriptomic analysis.
[Scientific Reports] |
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| Scientists showed in a unique site-directed knock-in embryonic stem cells model, that BCR-ABL expression tightly regulated by doxycycline controls the formation and the maintenance of immature hematopoietic progenitors.
[Experimental Hematology] |
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| Investigators described the impact of performance status, comorbidity, and physical functioning on overall survival in 115 older patients treated on a clinical trial with a 10-day decitabine schedule.
[Blood Cancer Journal] |
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| Researchers evaluated motixafortide, a high-affinity, long-acting CXCR4 inhibitor with rapid mobilizing kinetics, in a multi-center, open-label, single-arm, 2-part, Phase II study to mobilize hematopoietic stem and progenitor cells in allogeneic hematopoietic cell transplantation donors.
[Blood Advances] |
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| Investigators evaluated immune signatures at diagnosis and post-transplant relapse in bone marrow samples from four pediatric patients using a multimodal single-cell proteogenomic approach.
[Blood Advances] |
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| Scientists established an optimal model to predict the busulfan area under the curve at steady state by using machine learning.
[Expert Review Of Clinical Pharmacology] |
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| The authors discuss various cell sources for blood cell production, recent advances in manufacturing processes, and clinical applications of cultured blood.
[Biotechnology Progress] |
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| Scientists primarily focus on target selection and the corresponding research status of CAR-T therapy for AML, while also taking into account current interest in natural killer cells in relation to those targets.
[Biomarker Research] |
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| 2seventy bio, Inc. announced that the Phase I trial of the PLAT-08 study of SC-DARIC33 in AML has been paused by Seattle Children’s, the Company’s partner and the regulatory sponsor of the study.
[2seventy bio, Inc.] |
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| July 18 – 20, 2023
Boston, Massachusetts, United States |
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| | University of Texas Health Science Center San Antonio – San Antonio, Texas, United States |
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| | Fred Hutchinson Cancer Center – Seattle, Washington, United States |
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| | University Hospital RWTH Aachen – Aachen, Germany |
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| | Human Technopole – Milan, Italy |
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| | University of Michigan – Ann Arbor, Michigan, United States |
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Cancer Stem Cell News
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