 | | Vol. 14.25 – 27 June, 2023 |
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| Scientists reported the identification and expression of a new isoform splice variant of the tyrosine kinase receptor AXL in mantle cell lymphoma (MCL) cells. This new AXL isoform, AXL3, lacked the ligand-binding domain of the commonly described AXL splice variants and was constitutively activated in MCL cells.
[Blood] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
| | Investigators showed that disruption of the bi-cistronic microRNA locus miR-144/451 alleviated β-thalassemia by reducing mTORC1 activity and stimulating ULK1-mediated autophagy of free α-globin through two mechanisms.
[Blood] |
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| | Researchers demonstrated that targeting the homing signaling of hematopoietic stem/progenitor cells (HSPCs) elevated the proportions and biological functions of HSPCs in the in vivo osteo-organoid.
[Advanced Science] |
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| | Scientists investigated the impact of apoptosis inhibition on the hemostatic functions and survival of cold-stored platelets (CSPs). They found that blocking the transduction of the apoptotic signal induced by glycoprotein Ib (GPIb)-alpha clustering or the activation of caspase 9 did not impair CSPs functionality.
[Haematologica] |
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| | Researchers utilized the Eμ-TCL1 and EBI3 knock-out mouse models as well as clinical samples from patients to investigate the role of IL-27 in chronic lymphocytic leukemia.
[Haematologica] |
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| | Scientists developed a computational method to systematically identify RNA editing sites of cell types from scRNA-seq data. It was applied to scRNA-seq data of human hematopoietic stem/progenitor cells with an annotated lineage differentiation relationship and studied for the impacts of RNA editing on hematopoiesis.
[Scientific Reports] |
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| Researchers conducted a retrospective cohort study for patients undergoing allogeneic hematopoietic stem cell transplantation from 2006 to 2019. Catheter-related deep venous thrombosis and pulmonary embolism/lower-extremity deep venous thrombosis outcomes were screened.
[Thrombosis Research] |
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| Scientists identified the efficacy of haploidentical-related donor hematopoietic stem cell transplantation in adolescents and young adults with AML in a large cohort.
[British Journal Of Haematology] |
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| A total of 1967 patients with chronic-phase chronic myeloid leukemia diagnosed between 2012 and 2019 at 36 centers throughout Italy were retrospectively evaluated; 1089 patients received imatinib and 878 patients received a second-generation tyrosine kinase inhibitor.
[Cancer] |
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| Over the last decade, new therapeutic options and strategies have been developed for relapsed acute lymphoblastic leukemia (ALL) including immunotherapies and cellular therapies. It is imperative to understand how and when to use these newer approaches in relapsed ALL.
[Indian Journal Of Pediatrics] |
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| | Professor Harshal Nandurkar was awarded the member of the General Division as part of this year’s King’s Birthday Honours. He was recognized for his significant service to medicine, particularly as a hematologist.
[Monash University] |
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| July 9 – 14, 2023
Barcelona, Spain |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | University of Texas Health Science Center San Antonio – San Antonio, Texas, United States |
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| | Fred Hutchinson Cancer Center – Seattle, Washington, United States |
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| | University Hospital RWTH Aachen – Aachen, Germany |
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| | Human Technopole – Milan, Italy |
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