Hematopoiesis News Volume 14.27 | Jul 11 2023

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    2023-07-11 | HN 14.27


    Hematopoiesis News by STEMCELL Technologies
    Vol. 14.27 – 11 July, 2023
    TOP STORY

    Posttranslational Splicing Modifications as a Key Mechanism in Cytarabine Resistance in Acute Myeloid Leukemia

    Investigators showed that RNA splicing and serine-arginine-rich (SR) proteins phosphorylation were altered during cytarabine resistance. Moreover, phosphorylation of SR proteins at diagnosis was significantly lower in responder than non-responder patients, pointing to their utility to predict response.
    [Leukemia]

    Full Article
    Dr. Jackie Damen discusses why the CFU assay should be a vital part of your cell therapy workflow in this on-demand webinar.
    PUBLICATIONSRanked by the impact factor of the journal

    RUNX1 Mutations Mitigate Quiescence To Promote Transformation of Hematopoietic Progenitors in Fanconi Anemia

    In the context of the prototypical inherited bone marrow failure syndrome Fanconi anemia, researchers performed multiplexed gene editing of mutational hotspots in myelodysplastic syndrome-associated genes in human induced pluripotent stem cells followed by hematopoietic differentiation.
    [Leukemia]

    Abstract

    Dose-Dependent Expression of GFI1 Alters Metabolism in the Hematopoietic Progenitors and MLL::AF9-Induced Leukemic Cells

    Using in vitro and ex vivo murine models of MLL::AF9-induced human AML and extra-cellular flux assays, investigators demonstrated that a lower growth factor independence 1 (GFI1) expression enhanced oxidative phosphorylation rate via upregulation of the FOXO1- MYC axis.
    [British Journal Of Haematology]

    Full Article

    Enhanced In Vitro Type 1 Conventional Dendritic Cell Generation via the Recruitment of Hematopoietic Stem Cells and Early Progenitors by Kit Ligand

    Researchers presented a Kit ligand/Fms-like tyrosine kinase 3 ligand (KitL/Flt3L) protocol that recruited such HSCs and progenitors into the production of cDC1. KitL was used to expand HSCs and early progenitors lacking Flt3 expression into later stages where Flt3 was expressed.
    [European Journal Of Immunology]

    Abstract

    REDH: A Database of RNA Editome in Hematopoietic Differentiation and Malignancy

    Investigators established a new database, “REDH”, representing RNA editome in hematopoietic differentiation and malignancy. REDH was a curated database of associations between RNA editome and hematopoiesis.
    [Chinese Medical Journal]

    Full Article

    Acute Myeloid Leukemia Cells and MSC-Derived Exosomes Inhibiting Transformation in Myelodysplastic Syndrome

    Scientists investigated the mechanism of exosomes’ role in the transformation of myelodysplastic syndrome (MDS) to AML. Exosomes in culture supernatants of MDS and AML cell lines were extracted by ultrafiltration and identified in three ways: morphology, size, and exosome protein surface markers.
    [Discover Oncology]

    Full Article

    Pretransplant Spleen Volume and Outcome After Hematopoietic Stem Cell Transplantation (HSCT) in Patients With Acute Myeloid Leukemia (AML)

    Researchers investigated the predictive value of spleen volume on outcome parameters and engraftment kinetics after allogeneic HSCT in a large cohort of AML patients.
    [Annals Of Hematology]

    Full Article

    Results From a Phase I/II Trial of Cusatuzumab Combined With Azacitidine in Patients With Newly Diagnosed Acute Myeloid Leukemia Who Are Ineligible for Intensive Chemotherapy

    This two-part, open-label, multicenter, Phase I/II trial evaluated cusatuzumab plus azacitidine in patients with newly diagnosed AML ineligible for intensive chemotherapy. Patients received a single dose of cusatuzumab at one of four dose levels 14 days before starting combination therapy.
    [Haematologica]

    Full Article

    Clonal Hematopoiesis With DNMT3A and PPM1D Mutations Impairs Regeneration in Autologous Stem Cell Transplant Recipients

    Researchers performed targeted DNA sequencing of 457 HSC grafts collected for autologous stem cell transplantation in myeloma patients and correlated our findings with high-dimensional longitudinal clinical and laboratory data
    [Haematologica]

    Abstract
    Request your free copy of the 'Frequencies of Cell Types in Human Peripheral Blood' Wallchart
    REVIEWS

    Tumor-Associated Myeloid Cells in Cancer Immunotherapy

    The authors provide an overview of the literature with a focus on the recent research progress evaluating the heterogeneity of tumor-associated myeloid cell (TAMC) origins, summarizing therapeutic strategies targeting TAMCs with heterogeneous sources with their implications for cancer antitumor immunotherapies.
    [Journal Of Hematology & Oncology]

    Full Article
    INDUSTRY AND POLICY NEWS

    BioMarin Wins FDA Approval for First Gene Therapy for Hemophilia A

    The FDA has approved BioMarin Pharmaceutical’s valoctocogene roxaparvovec-rvox, to be marketed as Roctavian in the US. Roctavian, a one-time single-dose infusion, is authorized for use only in adults without antibodies against the adeno-associated virus serotype 5, as determined by an FDA-approved test.
    [BioSpace]

    Press Release
    FEATURED EVENT

    Overcoming Obstacles in Stem Cell Research: An Evening with the Stem Cell Podcast

    August 3, 2023
    New York, New York, United States

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    JOB OPPORTUNITIES

    Associate Researcher – Clonal Hematopoiesis

    University of Gothenburg – Gothenburg, Sweden

    Scientific Director – Clinical Research

    NCI Center for Cancer Research – Bethesda, Maryland, United States

    Technical Assistant – Hematopoiesis and Leukemia

    St. Anna Children’s Cancer Research Institute – Vienna, Austria

    Professor – Hematology & Oncology

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    Associate Professor – Pediatric Blood and Marrow Transplantation

    Fred Hutchinson Cancer Center – Seattle, Washington, United States

    > See All Jobs

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