 | | Vol. 14.28 – 18 July, 2023 |
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| Investigators attempted to identify responsible surface proteins and performed deep proteome profiling on minute numbers of dormant patient-derived xenograft (PDX) leukemia stem cells isolated from mice.
[Molecular Cancer] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists discovered that loss of microRNA (miR)-128 in zebrafish led to an expansion of hematopoietic stem and progenitor cells in the aorta–gonad–mesonephros with different cell cycle states and a skew towards erythroid and lymphoid progenitors.
[Nature Cell Biology] |
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| Investigators presented a new dual intron-targeting CRISPR-Cas9 treatment strategy, for targeting t(8;21) found in 5–10% of de novo AML, which efficiently disrupted fusion genes without prior identification of breakpoint location.
[Leukemia] |
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| Researchers integrated the analysis of primary AML and healthy samples, cancer cell lines, and a newly generated murine model, Vav1-iCre;Setbp1fl/fl. SETBP1 depletion in normal hematopoiesis minimally altered self-renewal, differentiation, or reconstitution in vivo.
[Leukemia] |
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| Scientists showed that megakaryocyte progenitors, megakaryocytes, and platelets presented a unique lipidome progressively enriched in polyunsaturated fatty acid (PUFA)-containing phospholipids.
[Nature Cardiovascular Research] |
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| Investigators used zebrafish to study the role of mcm10 during embryonic development and showed that mcm10 specifically regulated hematopoietic stem cell (HSC) emergence from the hemogenic endothelium.
[Stem Cell Reports] |
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| | Researchers conducted an investigator-initiated, multicenter, Phase Ib trial of AVID200 monotherapy in 21 advanced myelofibrosis patients.
[Clinical Cancer Research] |
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| Scientists conducted a multicenter, randomized, non-inferiority trial enrolling all consecutive adult patients undergoing high-dose-induction chemotherapy or hematopoietic stem cell transplantation with the objective to compare Non-Restrictive-Diet versus Protective-Diet.
[Blood Advances] |
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| This retrospective single-center study analyzed the neurologic complications in two subsequent cohorts of patients undergoing allogeneic hematopoietic stem cell transplantation with either calcineurin inhibitors (CNI)-based GVHD prophylaxis or CNI-free prophylaxis.
[Transplantation And Cellular Therapy] |
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| The authors update the infectious disease physician on newer advances in hematopoietic cell transplant and cellular therapy, including haploidentical transplant, expanding indications for transplant in older individuals and children, and chimeric antigen receptor T cells.
[Transplant Infectious Disease] |
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| | In October 2020, John Carlisle reported a startling estimate of the number of clinical-trial studies in medical journals that are fake or fatally flawed. For more than 150 trials, Carlisle got access to anonymized individual participant data and judged that 44% of the trials contained at least some flawed data.
[Nature] |
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| August 4 – 11, 2023
Newry, Maine, United States |
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| | University of Alberta – Edmonton, Alberta, Canada |
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| | University of Gothenburg – Gothenburg, Sweden |
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| | NCI Center for Cancer Research – Bethesda, Maryland, United States |
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| | St. Anna Children’s Cancer Research Institute – Vienna, Austria |
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| | Baylor College of Medicine – Houston, Texas, United States |
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