 | | Vol. 14.29 – 25 July, 2023 |
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| Researchers showed that loss of Tip49 triggered p53-dependent apoptosis and inhibited leukemia development in vivo. To examine the impact of chemical inhibition of this complex on leukemia, they developed the novel compound DS-4950, which interfered with the ATPase activity of the Tip48/49.
[Leukemia] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that AML leukemia initiating stem cells were sensitive to endogenous and exogenous cyclopentenone prostaglandin-J, Δ12-PGJ2, and 15d-PGJ2, which were increased upon dietary selenium supplementation via the cyclooxygenase-hematopoietic PGD synthase pathway.
[Cell Reports] |
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| Investigators studied lymphoma/leukemia-related activity in the evolving landscape of cells’ commitment to the erythroid lineage and specifically during fetal to adult hemoglobin transversion, to qualify transcription factors affecting chromatin remodeling as potential repressors of lncRNAs and miRNAs.
[Oncogene] |
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| Scientists found that the antifungal agent ciclopirox ethanolamine selectively supported immature CD34+CD90+ cells during culture and enhanced their long-term in vivo repopulation capacity.
[Blood Advances] |
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| Scientists investigated the effects of nucleoside diphosphate-linked moiety X-type motif 15 (NUDT15) R139C on hematopoietic stem cells upon thiopurine administration.
[Scientific Reports] |
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| Researchers showed that deubiquitinase USP9X stabilized ALKBH5 and promoted AML cell survival. Through the use of mass spectrometry as an unbiased approach, they identified USP9X and confirmed that it directly bound to ALKBH5.
[Journal Of Molecular Medicine] |
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| The effect of a benzene metabolite, 1,4-benzoquinone exposure, in hematopoietic stem and progenitor cells focusing on the self-renewing and differentiation pathways was investigated.
[PeerJ] |
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| Scientists performed genetic analyses, and evaluated prognostic factors and the value of allogeneic hematopoietic stem cell transplantation in a homogenous adult acute megakaryoblastic leukemia patient cohort.
[British Journal Of Haematology] |
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| Investigators retrospectively analyzed 451 patients who underwent allogeneic hematopoietic cell transplantation for AML in complete remission with either reduced intensity conditioning or myeloablative with the use of dual T cell depletion as graft-versus-host disease prophylaxis.
[European Journal Of Haematology] |
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| The authors review the emerging applications of single-cell techniques, and early results related to disease pathogenesis: effector and target cell populations and relationships; cell-autonomous and non-autonomous phenotypes in clonal hematopoiesis; transcript splicing; and chromosomal abnormalities.
[Blood] |
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| | Pluri Inc. will collaborate with the US Department of Defense’s Armed Forces Radiobiology Research Institute/Uniformed Services University of Health Sciences to further advance the development of its PLX-R18 cell therapy as a potential novel treatment for Hematopoietic Acute Radiation Syndrome.
[Pluri Inc. (Globe Newswire)] |
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| August 25 – 28, 2023
Amsterdam, Netherlands & Virtual |
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| | National Institutes of Health – Bethesda, Maryland, United States |
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| | University of Alberta – Edmonton, Alberta, Canada |
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| | University of Gothenburg – Gothenburg, Sweden |
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| | NCI Center for Cancer Research – Bethesda, Maryland, United States |
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| | St. Anna Children’s Cancer Research Institute – Vienna, Austria |
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