 | | Vol. 14.38 – 26 September, 2023 |
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| Researchers identified a key role for HEXIM1 in controlling erythroid gene expression and function, with overexpression of HEXIM1 promoting erythroid proliferation and fetal globin expression.
[Blood] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators revealed the critical role of a conserved amino acid, proline, at position 199, located at the 3’ end of the pointed domain, in ETS-related gene’s ability to induce leukemia.
[Nature Communications] |
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| Scientists showed that the m6A demethylase alkB homolog 5 (ALKBH5) controlled mitochondrial ATP production and modulated hematopoietic stem and progenitor cell fitness in an m6A-dependent manner.
[Cell Reports] |
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| Investigators established acquired pinometostat resistance in pediatric KMT2A::AFF1+ B-ALL cells.
[Experimental Hematology & Oncology] |
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| Researchers demonstrated that reticulocalbin-1 (RCN1) knockdown significantly suppressed the viability of bone marrow mononuclear cells from AML patients but did not affect the viability of granulocyte colony-stimulating factor-mobilized peripheral blood stem cells from healthy donors in vitro.
[Molecular Oncology] |
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| In this Phase I/II clinical trial, 65 pediatric and adult patients with refractory/relapsed T cell acute lymphoblastic leukemia and lymphoblastic lymphoma were enrolled.
[American Journal Of Hematology] |
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| Investigators conducted a registry analysis including adult acute myeloid leukemia (AML) patients in remission who had received thiotepa, busulfan, and fludarabine or treosulfan-basedconditioning for haplo-hematopoietic stem cell transplant with posttransplant cyclophosphamide between 2010 and 2020.
[Hemasphere] |
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| In the FORUM study, researchers assessed safety, event-free survival, and overall survival of two total-body irradiation-free conditioning regimens in children with high-risk or relapsed acute lymphoblastic leukemia <4 years old.
[Blood] |
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| Scientists investigated the use of elotuzumab, pomalidomide, and dexamethasone as salvage therapy prior to and maintenance after a second autologous hematopoietic cell transplant for relapsed multiple myeloma.
[Transplantation And Cellular Therapy] |
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| Scientists discuss the central role of the microenvironment in physiologic and pathologic hematopoiesis and the mechanisms of senescence, which is considered a fundamental protective mechanism against the proliferation of damaged and pre-tumoral cells.
[Experimental Hematology] |
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| Hematopoietic stem cell transplantation is a life-saving procedure that requires mobilization of stem cells for apheresis procedure. The authors examine mobilizing agents that are in use and under investigation.
[Journal Of Clinical Apheresis] |
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| Base editing, which makes specific changes to a cell’s genome, is put to the test in CAR-T-cell treatments for leukemia. The first participant had been treated using immune cells with four base-edited genes, equipping the cells to better target and destroy tumors.
[Nature] |
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| October 18 – 21, 2023
New York, New York, United States |
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| | University of North Carolina at Chapel Hill – Chapel Hill, North Carolina, United States |
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| | Houston Methodist Research Institute – Houston, Texas, United States |
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| | Cardiff University – Cardiff, Wales, United Kingdom |
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| | Versiti Blood Research Institute, – Wisconsin Rapids, Wisconsin, United States |
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| | The Sidney Kimmel Cancer Center – Philadelphia, Pennsylvania, United States |
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