 | | Vol. 14.41 – 17 October, 2023 |
| |
|
|
| Investigators employed single-cell RNA sequencing to identify eosinophil subgroups in mouse models of asthma and emphysema, followed by functional analyses of these subgroups.
[Signal Transduction And Targeted Therapy] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| The authors found that T-cell acute lymphoblastic leukemia cells require close contact with myeloid cells to survive.
[Nature Communications] |
|
|
|
| Scientists showed that knockout of aspartyl-tRNA synthetase 2 (Dars2) significantly impaired the maintenance of hematopoietic stem and progenitor cells without involving its tRNA synthetase activity.
[Cell Reports] |
|
|
|
| Scientists investigated the anti-proliferative effect of omipalisib in AML cell lines with varied genetic backgrounds. The OCI-AML3 and THP-1 cell lines had a significant response to omipalisib, with IC50 values of 17.45 nM and 8.93 nM, respectively.
[Cancer Gene Therapy] |
|
|
|
| Investigators demonstrated the growth-restraining function of HSCs in acute leukemia treatment. The viability, proliferation, apoptosis, and differentiation of leukemia cells were evaluated by cell counting, CCK-8, and flow cytometry analysis.
[Journal Of Cancer Research And Clinical Oncology] |
|
|
|
| The gain- and loss-of-function studies for neotumor ventral antigen-1 (NOVA1) were performed using lentivirus-mediated NOVA1 overexpression/knockdown in Jurkat and CCRF-CEM cells.
[Biochemistry And Cell Biology] |
| |
|
|
| In a multicenter cohort of 1606 newly diagnosed and intensively treated adult AML patients, researchers found IKZF1 alterations in 45 cases with a mutational hotspot at N159S.
[Leukemia] |
|
|
|
| Scientists retrospectively analyzed the association of clinical characteristics, comorbidities, and organ function with outcomes after conditioning with BCNU/carmustine, etoposide, cytarabine, and melphalan (BEAM) or thiotepa (TEAM).
[European Journal Of Haematology] |
|
|
|
| The authors compared transplant outcomes between refractory-T cell non-Hodgkin lymphomas (T-NHL) and Chemosensitive-T-NHL (CS-T-NHL). They reviewed the records of 26 refractory-NHL and 29 CS-T-NHL consecutive patients who underwent allogeneic stem cell transplantation.
[European Journal Of Haematology] |
|
|
|
|
| Investigators review the somatic mutations that accumulate in the blood and their connection to disease states, with a particular focus on inflammatory diseases and myelodysplastic syndrome.
[Annual Review Of Pathology-Mechanisms Of Disease] |
|
|
|
| Scientists discuss the current understanding of the role of mitochondrial metabolism in HSC transition from quiescence to activation and fate decisions.
[Experimental Hematology] |
|
|
|
|
| Editas Medicine, Inc. announced that the US FDA granted RMAT designation to EDIT-301, an investigational, gene editing medicine, for the treatment of severe sickle cell disease.
[Editas Medicine, Inc.] |
|
|
|
|
| November 2 – 4, 2023
Budapest, Hungary |
|
|
|
|
|
| | Cedars-Sinai – Los Angeles, California, United States |
|
|
|
| | Baylor College of Medicine – Houston, Texas, United States |
|
|
|
| | Georgetown University – Washington, Pennsylvania, United States |
|
|
|
| | University of San Francisco – San Francisco, California, United States |
|
|
|
| | University of Nebraska Medical Center – Omaha, Nebraska, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
