 | | Vol. 14.43 – 31 October, 2023 |
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| Researchers showed that in mice whose CXC chemokine ligand 12 (CXCL12) was deleted from half HSC niche cells, HSCs migrated from CXCL12-deficient niches to CXCL12-intact niches.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators reported a mechanistic link between disrupted DNA methylation at partially methylated domains and the spatial relocalization of H3K9me3-marked heterochromatin in aged hematopoietic stem and progenitor cells or those with impaired DNA methylation.
[Nature Aging] |
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| The authors investigated the role of interferon regulatory factor 1 (IRF1), a transcription factor that was affected by multiple inflammatory stimuli, in HSC regulation.
[Science Advances] |
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| Scientists described a mechanism that allowed communication between niche cells to coordinate their activity and shape the signaling environment surrounding resident stem cells.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| To understand the relevance of zinc finger and broad complex, tramtrak, bric-a-brac domain–containing 11 (ZBTB11) to mammalian systems, researchers studied its effects in definitive hematopoiesis in mice.
[Blood Advances] |
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| Investigators reported that platelet-derived growth factor (PDGF) signaling was required for erythroid progenitor differentiation.
[Development] |
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| The authors developed an AML patient-derived xenograft resource and performed integrated genomics, transcriptomics, and lipidomics analyses combined with functional genetics to identify key mediators of imetelstat efficacy.
[Nature Cancer] |
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| Scientists described the MSK-IMPACT Heme cohort, a comprehensive data set of somatic alterations from paired tumor and normal DNA using a hybridization capture-based next generation sequencing platform.
[Nature Communications] |
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| Researchers studied the expression and the variants of TET2 in Indian myelodysplastic Neoplasms (MDS) and AML-myelodysplasia-related patients and their effects on 5-hydroxymethyl cytosine (5-hmC) and on the prognosis of MDS patients.
[BMC Cancer] |
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| Scientists review the recent progress in the regulation of leukemogenesis via redox metabolism, especially redox biosensor-based findings.
[Trends in Cell Biology] |
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| The Department of Pediatrics at NYU Langone Health has received $9.8 million from NYU Langone trustee Trudy Elbaum Gottesman and Robert W. Gottesman, founding donors of Sala Institute for Child and Family Centered Care.
[NYU Langone Health] |
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| November 11 – 15, 2023
Nashville, Tennessee, United States |
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| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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