Hematopoiesis News Volume 14.44 | Nov 7 2023

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    Laurisa Dohm
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    2023-11-07 | HN 14.44


    Hematopoiesis News by STEMCELL Technologies
    Vol. 14.44 – 7 November, 2023
    TOP STORY

    The Bone Marrow Is the Primary Site of Thrombopoiesis

    The authors investigated the relative abundance of megakaryocytes in the adult murine bone marrow, spleen, and lung using whole-mount light sheet and quantitative histological imaging, flow cytometry, intravital imaging, and an assessment of scRNA-seq repositories.
    [Blood]

    Abstract
    Dr. Fabio Rossi discusses the role of mesenchymal stem cells in tissue repair and development.
    PUBLICATIONSRanked by the impact factor of the journal

    BloodSpot 3.0: A Database of Gene and Protein Expression Data in Normal and Malignant Hematopoiesis

    BloodSpot is a specialised database integrating gene expression data from AML patients related to blood cell development and maturation.
    [Nucleic Acids Research]

    Full Article
    Graphical Abstract

    Slow Cycling and Durable Flt3+ Progenitors Contribute to Hematopoiesis under Native Conditions

    Using CITE-seq analyses, the authors uncovered a distinct progenitor population that displayed a cell cycle gene signature similar to the one found in quiescent HSCs.
    [Journal of Experimental Medicine]

    Abstract

    Insights into Highly Engraftable Hematopoietic Cells from 27-Year Cryopreserved Umbilical Cord Blood

    Investigators demonstrated that long-term cryopreserved cord blood retained similar numbers of hematopoietic stem and progenitor cells compared with fresh and recently cryopreserved cord blood units.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract

    Erythroid Differentiation Enhances RNA Mis-Splicing in SF3B1-Mutant Myelodysplastic Syndromes with Ring Sideroblasts

    Researchers combined successful direct ring sideroblasts (RS) isolation from patient samples, high-throughput multiomics analysis of cells encompassing the SF3B1mt stem-erythroid continuum, and functional assays to investigate the impact of SF3B1mt on erythropoiesis and RS accumulation.
    [Cancer Research]

    Abstract

    ASXL1 Mutations Are Associated with a Response to Alvocidib and 5-Azacytidine Combination in Myelodysplastic Neoplasms

    Mutational profiling of myelodysplastic syndromes (MDS) samples identified ASXL1 mutations as predictors of response. Further, increased response rates were associated with higher gene-expression of the pro-apoptotic factor NOXA in ASXL1 mutated samples.
    [Haematologica]

    Abstract

    Synergistic Roles of DYRK1A and GATA1 in Trisomy 21 Megakaryopoiesis

    To determine how DYRK1A influenced hematopoiesis in concert with GATA1s, investigators used gene editing to disrupt all three alleles of DYRK1A in isogenic T21 induced pluripotent stem cells with and without the GATA1s mutation.
    [JCI Insight]

    Abstract

    Fixed-Duration Ibrutinib–Venetoclax Versus Chlorambucil–Obinutuzumab in Previously Untreated Chronic Lymphocytic Leukemia (GLOW): 4-Year Follow-Up from a Multicentre, Open-Label, Randomised, Phase III Trial

    In the GLOW study, fixed-duration ibrutinib–venetoclax showed superior progression-free survival versus chlorambucil–obinutuzumab in patients with previously untreated chronic lymphocytic leukemia who were older or had comorbidities, or both, at a median follow up of 27·7 months.
    [Lancet Oncology]

    Abstract

    Radioimmunotherapy Versus Autologous Hematopoietic Stem Cell Transplantation in Relapse/Refractory Follicular Lymphoma: A Fondazione Italiana Linfomi Multicenter, Randomized, Phase III Trial

    Patients age 18–65 years with relapsed/refractory ollicular lymphoma and without significant comorbidities were enrolled and treated with three courses of conventional, investigator-chosen chemoimmunotherapies.
    [Annals Of Oncology]

    Full Article
    Request your free copy of the 'Directed Differentiation of Pluripotent Stem Cells' Wallchart
    REVIEWS

    Mechanisms of Resistance to Chimeric Antigen Receptor-T Cells in Hematological Malignancies

    The authors summarize the resistance mechanisms to CAR-T cell immunotherapy by analysing CAR-T cell dysfunction, intrinsic tumor resistance, and the immunosuppressive tumor microenvironment.
    [Nature Reviews Drug Discovery]

    Abstract

    Activating Transcription Factor 4 in Erythroid Development and β-Thalassemia: A Powerful Regulator with Therapeutic Potential

    Recent research has suggested that activating transcription factor 4 contributes to decreased fetal hemoglobin level through its binding to potent negative regulators of HbF, such as BCL11A and MYB.
    [Annals of Hematology]

    Abstract
    INDUSTRY AND POLICY NEWS

    House Lawmakers Launch Probe Into FDA’s Response to Nationwide Drug Shortages

    As shortages of drugs like amoxicillin, penicillin, Adderall and certain chemotherapies continue to confound doctors and patients in the US, two high-ranking Republican lawmakers are pressing the FDA for answers.
    [Fierce Pharma]

    Editorial
    FEATURED EVENT

    Donor Selection & Cell Source Summit

    November 28 – 30, 2023
    San Francisco, California, United States

    > See All Events

    JOB OPPORTUNITIES

    Laboratory Director – Biobank

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Scientist – Cancer Research Cluster

    Cedars-Sinai – Los Angeles, California, United States

    Research Associate – Hematology & Cellular Therapy

    Cedars-Sinai – Los Angeles, California, United States

    Postdoctoral Associate – Immune Cells in Blood Diseases and GvHD

    Baylor College of Medicine – Houston, Texas, United States

    Doctoral Positions – Biomedical Research

    Berlin Institute of Health at Charit̩ РBerlin, Germany

    > See All Jobs

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