 | | Vol. 14.46 – 21 November, 2023 |
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| Researchers used whole-genome sequencing to track HSCs from six patients with sickle cell disease at pre- and post-gene therapy time points to map the somatic mutation and clonal landscape of gene-modified and unmodified HSCs.
[Nature Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists used single-cell RNA sequencing and single-cell ATAC sequencing to profile 28 patients representing different pediatric AML subtypes at diagnosis, remission and relapse.
[Cancer Cell] |
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| Investigators demonstrated that NOD1, a cytosolic innate sensor of bacterial peptidoglycan, also functioned in murine hematopoietic cells as a major regulator of both the generation and differentiation of lymphoid progenitors as well as peripheral T lymphocyte homeostasis.
[Nature Immunology] |
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| Researchers performed metabolomics of red blood cell units at storage day 10, 23 and 42 for a total of 1,929 samples, and also characterized for end of storage hemolytic propensity following oxidative and osmotic insults.
[Blood] |
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| The authors developed a therapeutic LAIR-1 agonist antibody, NC525, that induced cell death of leukemic stem cells (LSCs), but not healthy hematopoietic stem cells in vitro, and killed LSCs and AML blasts in both cell- and patient-derived xenograft models.
[Journal Of Clinical Investigation] |
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| Differentiation of CD34+ hematopoietic progenitors in vitro showed that cells with GATA1 antisense transcription had enhanced GATA2 transcription and a mast cell phenotype, whereas cells with GATA2 antisense transcription had increased GATA1 transcripts and an erythroblast phenotype.
[Cell Reports] |
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| The authors found that the miR-221/222 cluster, which was expressed in HSC and in multipotent progenitors differentiating from them, perturbed steady-state hematopoiesis in ways comparable to stress.
[PLOS Biology] |
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| | Data were collected for consecutive children and young persons aged 1-24 years with Philadelphia chromosome–positive or Philadelphia chromosome–negative B-ALL who received blinatumomab as first-line therapy.
[Journal Of Clinical Oncology] |
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| Scientists tested the association of clonal hematopoiesis of indeterminate potential with new-onset arrhythmias. UK Biobank participants without prevalent arrhythmias were included. Co-primary study outcomes were supraventricular arrhythmias, bradyarrhythmias, and ventricular arrhythmias.
[European Heart Journal] |
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| Prior to and during pregnancy, in addition to the assessment and care that every pregnant patient should receive, patients with sickle cell disease should be evaluated and treated by a multidisciplinary team with respect to their unique maternal and fetal issues.
[Blood] |
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| Vertex and CRISPR Therapeutics have scored authorization in the UK for their exa-cel gene therapy to treat patients with severe forms of sickle cell and transfusion-dependent beta thalassemia, two genetic disorders of the blood.
[Fierce Pharma] |
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| December 4 – 7, 2023
Dublin, Ireland |
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| | University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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| | University of York – York, England, United Kingdom |
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| | University of York – York, England, United Kingdom |
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| | Applied Stem Cell – Milpitas, California, United States |
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| | Masaryk University – Brno, Czech Republic |
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