Hematopoiesis News Volume 14.48 | Dec 5 2023

December 5, 2023

2023-12-05 | HN 14.48

Hematopoiesis News by STEMCELL Technologies

Vol. 14.48 – 5 December, 2023

TOP STORY

Breast Cancer Remotely Imposes a Myeloid Bias on Haematopoietic Stem Cells by Reprogramming the Bone Marrow Niche

Using unbiased transcriptomic analysis and in situ imaging of HSCs and the bone marrow niche during breast cancer, researchers showed that both HSCs and mesenchymal stem cells were transcriptionally and spatially modified.
[Nature Cell Biology]

Abstract

Request a free copy of this wallchart on mouse HSPC subsets, including their frequencies and phenotypes.

PUBLICATIONSRanked by the impact factor of the journal

Data-Driven Grading of Acute Graft-Versus-Host Disease

The authors analyzed acute graft-versus-host disease phenotypes and clinical classifications in depth in large, multicenter cohorts involving 3019 patients, and addressed prevailing gaps by developing data-driven models.
[Nature Communications]

Full Article

ROBO1 Deficiency Impairs HSPC Homeostasis and Erythropoiesis via CDC42 and Predicts Poor Prognosis in MDS

Robo1 deficiency impaired HSPC homeostasis and disrupted HSPC pool, especially the reduction of megakaryocyte erythroid progenitors, which caused a blockage in the early stages of erythropoiesis in mice.
[Science Advances]

Full Article

Harnessing T Cell Exhaustion and Trogocytosis to Isolate Patient-Derived Tumor-Specific TCR

Investigators typed the frequency, phenotype, and function of lymphocytes directed against tumor-associated antigens in 39 consecutive transplanted patients, for one year after transplant.
[Science Advances]

Full Article

RAB27B-Regulated Exosomes Mediate LSC Maintenance via Resistance to Senescence and Crosstalk with the Microenvironment

Scientists found that increased RAB27B in leukemia stem cells prevented their senescence and maintained their stemness in vitro and in vivo.
[Leukemia]

Abstract

Clonal Hematopoiesis with DNMT3A and PPM1D Mutations Impairs Regeneration in Autologous Stem Cell Transplant Recipients

Researchers performed targeted DNA sequencing of 457 hematopoietic stem cell grafts collected for autologous stem cell transplantation in myeloma patients and correlated their findings with high-dimensional longitudinal clinical and laboratory data.
[Haematologica]

Full Article

SRSF2 Mutation Reduces Polycythemia and Impairs Hematopoietic Progenitor Functions in JAK2V617F-Driven Myeloproliferative Neoplasm

Scientists showed that co-expression of Srsf2^P95H mutant reduced red blood cell, neutrophil, and platelet counts,and attenuated splenomegaly, but did not induce bone marrow fibrosis in the Jak2^V617F/+ mice.
[Blood Cancer Journal]

Full Article

CLINICAL RESEARCH

Outcomes of CMML Patients Undergoing Allo-HCT Are Significantly Worse Compared to MDS—A Study of the CMWP of the EBMT

Patients ≥18 years with chronic myelomonocytic leukemia and myelodysplastic syndromes undergoing hematopoietic cell transplantation reported to the EBMT registry were analyzed.
[American Journal Of Hematology]

Full Article

Effects of Dapagliflozin and Dapagliflozin-Saxagliptin on Erythropoiesis, Iron and Inflammation Markers in Patients with Type 2 Diabetes and Chronic Kidney Disease: Data from the DELIGHT Trial

Researchers measured hemoglobin, iron markers, plasma erythropoietin, and inflammatory markers at baseline and week 24.
[Cardiovascular Diabetology]

Full Article

Learn more about isolating human NK cells with ease

REVIEWS

Pathobiology of Nodal Peripheral T-Cell Lymphomas: Current Understanding and Future Directions

The authors summarize current knowledge of the pathology and biology of nodal-based peripheral T- and NK- cell lymphoma entities, with an emphasis on recent findings and underlying oncogenic mechanisms.
[Haematologica]

Full Article

INDUSTRY AND POLICY NEWS

Lilly’s Jaypirca Blazes Leukemia Trail with FDA Nod, Fast Confirmatory Trial Filing

On December 1, the FDA granted accelerated approval to Lilly’s Jaypirca for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma who have received at least two prior lines of therapy.
[Fierce Pharma]

News Article

FEATURED EVENT

Hematopoiesis News Volume 14.48 | Dec 5 2023

Breast Cancer Remotely Imposes a Myeloid Bias on Haematopoietic Stem Cells by Reprogramming the Bone Marrow Niche

Data-Driven Grading of Acute Graft-Versus-Host Disease

ROBO1 Deficiency Impairs HSPC Homeostasis and Erythropoiesis via CDC42 and Predicts Poor Prognosis in MDS

Harnessing T Cell Exhaustion and Trogocytosis to Isolate Patient-Derived Tumor-Specific TCR

RAB27B-Regulated Exosomes Mediate LSC Maintenance via Resistance to Senescence and Crosstalk with the Microenvironment

Clonal Hematopoiesis with DNMT3A and PPM1D Mutations Impairs Regeneration in Autologous Stem Cell Transplant Recipients

SRSF2 Mutation Reduces Polycythemia and Impairs Hematopoietic Progenitor Functions in JAK2V617F-Driven Myeloproliferative Neoplasm

Outcomes of CMML Patients Undergoing Allo-HCT Are Significantly Worse Compared to MDS—A Study of the CMWP of the EBMT

Effects of Dapagliflozin and Dapagliflozin-Saxagliptin on Erythropoiesis, Iron and Inflammation Markers in Patients with Type 2 Diabetes and Chronic Kidney Disease: Data from the DELIGHT Trial

Pathobiology of Nodal Peripheral T-Cell Lymphomas: Current Understanding and Future Directions

Lilly’s Jaypirca Blazes Leukemia Trail with FDA Nod, Fast Confirmatory Trial Filing

6th DNA Repair/Replication Structures and Cancer Conference

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PhD Positions – Tissue Regeneration and Cancer Immunotherapy

Animal Technician – Experimental Therapeutics

PhD Position – Aging of Human Hematopoietic Stem Cells

Postdoctoral Associate – Hemostasis and Thromboinflammation in Sickle Cell Disease

PhD Position – Expanding Blood Stem Cells

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