Hematopoiesis News Volume 15.01 | Jan 16 2024

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    2024-01-15 | HN 15.02


    Hematopoiesis News by STEMCELL Technologies
    Vol. 15.01 – 16 January, 2024
    TOP STORY

    Inherited Blood Cancer Predisposition through Altered Transcription Elongation

    Performed rare variant association studies in a large population cohort to identify inherited predisposition genes for these blood cancers.
    [Cell]

    Full ArticleGraphical Abstract
    Request a free copy of this wallchart on mouse HSPC subsets, including their frequencies and phenotypes.
    PUBLICATIONSRanked by the impact factor of the journal

    A Time- and Single-Cell-Resolved Model of Murine Bone Marrow Hematopoiesis

    Scientists combined persistent labeling with time-series single-cell RNA sequencing to build a real-time, quantitative model of in vivo tissue dynamics for murine bone marrow hematopoiesis.
    [Cell Stem Cell]

    Full ArticleGraphical Abstract

    RNA-Binding Protein RBM5 Plays an Essential Role in Acute Myeloid Leukemia by Activating the Oncogenic Protein HOXA9

    Investigators performed genome-wide CRISPR/Cas9 screening in the HOXA9-driven reporter acute leukemia cells. They identified a poorly characterized RNA-binding protein, RBM5, as the top candidate gene required to maintain leukemia cell fitness.
    [Genome Biology]

    Full Article

    Evaluation of the Genetic Basis of Familial-Associated Early-Onset Hematologic Cancers in an Ancestral/Ethnically Diverse Population

    Scientists performed exome sequencing on DNA isolated from newborn bloodspots derived from sibling pairs with early-onset cancers across California in which at least one of the siblings developed a hematologic cancer, using unbiased recruitment from the full state population.
    [Haematologica]

    Abstract

    In Vivo Measurement of RBC Survival in Patients with Sickle Cell Disease before or after Hematopoietic Stem Cell Transplantation

    Researchers utilized biotin-labeling of red blood cells (RBCs) to determine the lifespan of RBCs in patients with sickle cell disease compared to patients who have successfully undergone curative hematopoietic stem cell transplantation, participants with sickle cell trait, and healthy donors.
    [Blood Advances]

    Abstract

    Bone Marrow Macrophages Are Involved in the Ineffective Hematopoiesis of Myelodysplastic Syndromes

    Flow cytometry analysis showed increased pro-inflammatory monocyte subsets and a decreased classically activated MΦs/alternatively activated MΦs ratio in the bone marrow of patients with higher-risk Myelodysplastic syndromes (MDS) compared to lower-risk MDS.
    [Journal Of Cellular Physiology]

    Full Article

    Schistosome Infection Impacts Hematopoiesis

    The authors describe the hematopoietic response to infection of mice with Schistosoma mansoni, a parasitic flatworm that causes schistosomiasis.
    [Journal Of Immunology]

    Abstract

    Bone Marrow Graft versus Peripheral Blood Graft in Haploidentical Hematopoietic Stem Cells Transplantation: A Retrospective Analysis in1344 Patients of SFGM-TC Registry

    A total of 1344 adult patients received an unmanipulated haploidentical transplant at 37 centers from 2012 to 2019 for hematologic malignancy.
    [Journal Of Hematology & Oncology]

    Full Article

    Fludarabine, Cytarabine, and Idarubicin with or without Venetoclax in Patients with Relapsed/Refractory Acute Myeloid Leukemia

    This retrospective cohort study compared safety and efficacy of fludarabine, cytarabine, and idarubicin without or with venetoclax in patients with relapsed and refractory acute myeloid leukemia patients.
    [Haematologica]

    Full Article

    Allogeneic Hematopoietic Cell Transplantation for Therapy-Related Myeloid Neoplasms Arising Following Treatment for Lymphoma: A Retrospective Study on Behalf of the Chronic Malignancies Working Party of the EBMT

    The authors analyzed outcomes of 378 patients undergoing first llogeneic haematopoietic cell transplantation between 2006–2017 for t-MN arising secondary to lymphoma treatment.
    [Bone Marrow Transplantation]

    Abstract

    Analysis of Laboratory Parameters before the Occurrence of Hepatic Sinusoidal Obstruction Syndrome in Children, Adolescents, and Young Adults after Hematopoietic Stem Cell Transplantation

    Researchers investigated laboratory parameters following hematopoietic stem cell transplantation that can predict the occurrence of sinusoidal obstruction syndrome.
    [Journal Of Cancer Research And Clinical Oncology]

    Full Article
    Ready-to-use, ethically sourced cryopreserved human PB pan-T cells. Click to learn more.
    REVIEWS

    Effects of Fine Particulate Matter on Bone Marrow-Conserved Hematopoietic and Mesenchymal Stem Cells: A Systematic Review

    With an emphasis on the invasive characteristics of PM2.5, the authors examine the current knowledge of the health effects of PM2.5 exposure on bone marrowresiding stem cells.
    [Experimental & Molecular Medicine]

    Full Article
    INDUSTRY AND POLICY NEWS

    GFH009 Receives FDA Fast Track, Orphan Drug Designations for Treating R/R Peripheral T-cell Lymphomas and Acute Myeloid Leukemia

    GenFleet Therapeutics announced that the FDA has granted another two designations for SLS009 (GFH009). GFH009 so far has received both Fast Track Designation and Orphan Drug Designation for the treatment of adult patients with relapsed/refractory peripheral T cell lymphomas and r/r acute myeloid leukemia.
    [GenFleet Therapeutics]

    Press Release
    FEATURED EVENT

    CSMBMEET2024

    March 11 – 13, 2024
    Lisbon, Portugal

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Tumor Microenvironment and Leukemia

    City of Hope – Duarte, California, United States

    Research Assistant – Hematopoietic Biology & Malignancy

    MD Anderson Cancer Center – Houston, Texas, United States

    Research Associate – Translational Pediatric Oncology

    City of Hope – Duarte, California, United States

    Research Assistant – Hematopoietic Biology & Malignancy

    MD Anderson Cancer Center – Houston, Texas, United States

    PhD Positions – Tissue Regeneration and Cancer Immunotherapy

    Albert-Ludwigs-University Freiburg – Freiburg im Breisgau, Germany

    > See All Jobs

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