 | | Vol. 15.02 – 23 January, 2024 |
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| Investigators showed that the inherited polygenic loci that underlie common hematological traits influenced JAK2V617F clonal expansion.
[Nature Genetics] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers used combined transcriptomic data derived from peripheral blood mononuclear cells of heart failure patients, both with and without CHIP, and cardiac tissue.
[Nature Communications] |
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| Scientists observed that RNA N1-methyladenosine-generating methyltransferase TRMT6–TRMT61A complex was increased in aged murine HSCs due to aging-declined CRL4DCAF1-mediated ubiquitination degradation signaling.
[Nature Aging] |
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| The authors investigated the functional involvement of MITOL in HSC maintenance by generating MX1-cre inducible Mitol knockout mice.
[EMBO Journal] |
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| In two separate congenic models of AML researchers confirmed by evaluation of the bone marrow plasma secretome and HSPC-selective single-cell RNA sequencing that multipotent progenitors and long-lived stem cells adopted inflammatory gene expression programs.
[Leukemia] |
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| Scientists demonstrated that similar to a RIPK3 deficiency, an MLKL deficiency significantly extended survival and like Ripk3 deficiency partially restored hematopoiesis in Ripk1HEM KO mice revealing that both necroptosis and apoptosis contributed to bone marrow failure in these mice.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Investigators hypothesized that the co-occurrence of CHIP and mCAs at the same locus might have important prognostic implications for malignancy transformation risk.
[Blood Cancer Journal] |
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| Researchers investigated the effects of thrombopoietin (TPO) and its receptor MPL ablation on marrow and splenic hematopoiesis in TPO−/− and MPL−/− mice during aging.
[Stem Cell Reports] |
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| 297 individuals with overweight and obesity, between the ages of 54 and 81 years, were recruited in a cross‐sectional study. Clonal hematopoiesis driver mutations were identified with an ultrasensitive targeted assay.
[Journal Of The American Heart Association] |
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| The extent of dosage reduction recommended for patients with intermediate activity in both enzymes is currently not clear. Mercaptopurine dosages during maintenance were collected from 1768 patients with acute lymphoblastic leukemia in Singapore, Guatemala, India, and North America.
[JNCI-Journal Of The National Cancer Institute] |
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| This retrospective study aimed to identify the group of patients who safely undergo allogeneic hematopoietic stem cell transplantation with low-dose fluconazoleprophylaxis
[Cancer Medicine] |
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| Scientists discuss ex vivo culture protocols for expanding human HSCs and present the results of clinical trials using these techniques, along with future perspectives.
[Cancer Science] |
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| The US health regulator on asked a host of drugmakers, including Gilead Sciences, Johnson & Johnson, and Novartis to add a serious warning on the label of their cancer therapies that use CAR-T technology.
[Reuters] |
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| March 13 – 15, 2024
Erlangen, Germany |
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| | MD Anderson Cancer Center – Houston, Texas, United States |
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| | Karolinska Institutet – Huddinge, Sweden |
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| | City of Hope – Duarte, California, United States |
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| | MD Anderson Cancer Center – Houston, Texas, United States |
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| | Albert-Ludwigs-University Freiburg – Freiburg im Breisgau, Germany |
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