 | | Vol. 15.05 – 13 February, 2024 |
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| The authors demonstrated that inhibition of tyrosine phosphatase SHP-1 in leukemia stem cells increased their glycolysis and oxidative phosphorylation, enhancing their sensitivity to chemotherapy and vulnerability to immunosurveillance.
[Nature Cell Biology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators developed gene editing strategies targeting a corrective sequence into the human RAG1 gene by homology-directed repair and validated them by tailored 2D, 3D, and in vivo xenotransplant platforms to assess rescue of expression and function.
[Science Translational Medicine] |
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| The 3D digital rolling circle amplification technique presented could distinguish BCR-ABL1 fusion transcript positive B-cell acute lymphoblastic leukemia cells with or without CD19 protein expression.
[ACS Nano] |
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| Scientists used a chimeric mouse model of chronic myeloid leukaemia and human bone marrow (BM) derived macrophages to study the impact of the dysregulated BM microenvironment on bystander macrophages.
[Nature Communications] |
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| By using a conditional knockout mouse model in which Ppm1b was specifically depleted in hematopoietic cells, researchers demonstrated that loss of Ppm1b impaired the HSC homeostasis and hematopoietic reconstitution.
[Haematologica] |
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| Using a combination of expression analysis, time-lapse imaging, and lineage-tracing approaches, investigators demonstrated that myeloid cells emerged from the endocardium in zebrafish embryos.
[Cell Reports] |
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| Scientists characterized the hepatic immune compartment of a neonatal peroxisome biogenesis disorders mouse model at single-cell resolution to establish the importance and function of peroxisomes in developmental hematopoiesis.
[Cell Reports] |
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| Patients aged 65 years or older with newly diagnosed, untreated primary diffuse large B cell CNS lymphoma were enrolled if they had an Eastern Cooperative Oncology Group performance status of 0–2 and were fit for high-dose chemotherapy and autologous HSCT.
[Lancet Haematology] |
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| Researchers compared the outcomes between Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) patients who did or did not undergo allogeneic stem cell transplantation in the first complete remission.
[American Journal Of Hematology] |
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| The authors summarize the most updated treatment recommendations for pediatric chronic myeloid leukemia, and to discuss current areas of investigation.
[Current Oncology Reports] |
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| The company will stop testing the drug, magrolimab, for all blood cancers and will review its safety across other studies such as those in patients with colon and breast cancers.
[Reuters] |
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| April 4 – 5, 2024
Cincinnati, Ohio, United States |
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| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | BC Provincial Health Services Authority – Vancouver, British Columbia, Canada/p> |
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| | University of Maryland Baltimore – Baltimore, Maryland, United States |
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| | City of Hope – Duarte, California, United States |
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| | Human Technopole – Milan, Italy |
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