 | | Vol. 15.08 – 5 March, 2024 |
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| Investigators used a GATA2-deficient progenitor rescue system to analyze how genetic variation influences GATA2 functions.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists identified HIFhigh and HIFlow specific AML subgroups and provided a comprehensive single-cell expression atlas of 119,000 AML cells and AML-leukemia stem cells in paired diagnostic-relapse samples from these molecular subgroups.
[Hemasphere] |
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| Researchers utilized a defined cocktail of cytokines without serum or feeder followed by the supplementation of ASPP 049 to produce hematopoietic stem/progenitor cells.
[Stem Cell Research & Therapy] |
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| The hypomorphic allele of SMARCA5 could rescue not only the developmental arrest in hematopoiesis in the hCD2iCre model but also the lethal phenotypes associated with constitutive Smarca5 deletion or Vav1iCre-driven conditional knockout in hematopoietic progenitor cells.
[Communications Biology] |
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| Investigators measured the vasopressin marker copeptin and markers of erythropoiesis, red blood cell distribution width, mean corpuscular volume, erythrocyte volume fraction, leukocyte count, and thrombocyte count in 5312 participants from the Swedish CArdioPulmonary bioImage study.
[Scientific Reports] |
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| Researchers showed that the chemotherapeutic drug etoposide reduced the protein levels of several isoforms of Ikaros including IK1, IK2 and IK4, but not IK6 or IK7, by accelerating protein degradation, in leukemic cells.
[Biological Chemistry] |
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| The capacity of mesenchymal stem cells derived from different sources to support the expansion and maintenance of HSPC was compared with each other.
[Tissue And Cell] |
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| Scientists reported efficacy, pharmacokinetics, and safety data obtained in treatment-naive, pediatric patients with newly diagnosed advanced myelodysplastic syndromes receiving azacitidine in the AZA-JMML-001 study.
[Pediatric Blood & Cancer] |
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| Investigators presented a pediatric case that manifested as PML::RARA-negative acute promyelocytic leukemia with central nervous system involvement at onset. The patient experienced both intramedullary and extramedullary relapse one year after undergoing allogeneic hematopoietic stem cell transplantation.
[Heliyon] |
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| Leukemogenesis occurs and progresses in extracellular microvesicles enriched microenvironments. The authors present a current point of view on this topic and review some selected most recent discoveries and papers.
[Leukemia] |
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| Investigators describe how chromobox (CBX) proteins dictate age-related changes in HSCs and stimulate oncogenic HSC fate decisions, either as canonical polycomb repressive complex 1 members or by alternative interactions, including non-epigenetic regulation.
[FEBS Letters] |
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| Congratulations to the BC Cancer researchers who are recipients of the 2023 Canadian Cancer Society Challenge Grants Competition. The grants supported cancer research projects with the ultimate goal of solving a problem in cancer that is meaningful to people affected by or at risk of cancer.
[BC Cancer Research] |
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| April 15 – 16, 2024
London, England, United Kingdom |
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| | University Medical Center Groningen – Groningen, Netherlands |
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| | Georg-Speyer-Haus – Frankfurt, Germany |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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| | Luxembourg Institute of Health – Strassen, Luxembourg |
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| | University of Alberta – Edmonton, Alberta, Canada |
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