 | | Vol. 15.10 – 19 March, 2024 |
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| Investigators uncovered CNOT3, a subunit of the CCR4-NOT complex, as an essential modulator of translation in myeloid leukemia. Elevated CNOT3 expression correlated with unfavorable outcomes in patients with AML.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Using combined approaches, including scRNA-seq, researchers confirmed that autophagy-related gene 5 deletion interrupted developmental temporal order of endothelial to hematopoietic transition to further affect the pre-HSC I maturation.
[Nature Communications] |
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| The authors developed mixed bone marrow chimeric mice with inducible Stat3 deletion in 20% of the hematopoietic compartment to avoid systemic inflammation. Stat3-deficient HSPCs were significantly impaired in reconstitution ability following primary or secondary bone marrow transplantation.
[Leukemia] |
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| Investigators showed that NFKBIE-mutated CLL cells were selected by microenvironmental signals that activated the NF-κB pathway and induced alterations within the tumor microenvironment that could allow for immune escape.
[Leukemia] |
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| Scientists mapped an atlas of terminally differentiated cells from umbilical cord blood mononuclear cells and pluripotent stem cells, and observed their dynamic regulation of erythropoiesis at single-cell resolution.
[Cell Proliferation] |
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| Researchers showed that the ATP-binding cassette transporter 10 (Abcb10), located on the inner mitochondrial membrane, was essential for HSC maintenance and erythroid lineage differentiation.
[Experimental Hematology] |
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| | Adults with FLT3-ITD AML in first remission underwent hematopoietic cell transplantation (HCT) and were randomly assigned to placebo or 120mg once daily gilteritinib for 24 months after HCT. The primary end point was relapse-free survival.
[Journal Of Clinical Oncology] |
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| Investigators examined whether clonal hematopoiesis of indeterminate potentia was associated with HCC development in patients with steatotic liver disease.
[Hepatology] |
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| Researchers utilized clinical data from studies of an anti-Oncostatin M (OSM) monoclonal antibody in healthy volunteers and systemic sclerosis patients, to quantitatively determine the link between OSM and alterations in red blood cell and platelet production.
[Clinical Pharmacology & Therapeutics] |
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| The authors provide an overview of our current understanding of inflammatory changes in the bone marrow microenvironment of myeloid and lymphoid malignancies, using AML and multiple myeloma as examples.
[Nature Reviews Immunology] |
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| Scientists review the mechanisms of progression focusing on the hierarchy of clonal mutation and potential roles of transcription factor alterations, splicing factor mutations, and the bone marrow environment in progression to AML.
[Blood] |
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| The American Association for Cancer Research has awarded Dr. Owen Witte, founding director emeritus of the UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, with the 2024 Award for Outstanding Achievement in Blood Cancer Research.
[UCLA] |
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| April 24 – 26, 2024
Vienna, Austria |
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| | Universitätsklinikum Köln – Cologne, Germany |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | Georg-Speyer-Haus – Frankfurt, Germany |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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