 | | Vol. 15.11 – 26 March, 2024 |
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| Scientists developed strategies to image multipotent hematopoiesis, erythropoiesis, and lymphopoiesis in mice. They combined these with imaging of myelopoiesis to define the anatomy of normal and stress hematopoiesis.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Through RNA-sequencing analysis, researchers identified that IL-1 upregulated anti-silencing function-1B (ASF1B), a histone chaperone, in AML progenitors compared to healthy progenitors.
[Blood] |
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| To track the output and clonality of homology-directed repair-edited cells and to provide a comparison to lentivirally transduced HSCs in vivo, investigators developed a competitive rhesus macaque autologous transplantation model.
[Cell Stem Cell] |
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| Scientists identified the expression of nitric oxide synthase in blood progenitors, generating nitric oxide for post-translational S-nitrosylation of protein cysteine residues.
[Developmental Cell] |
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| Investigators introduced mutations in the mouse germline and reported a consistent physiological requirement for Mpl-Y599, mutation of which resulted in thrombocytopenia, deficient megakaryopoiesis, low HSC number and function, and attenuated responses to myelosuppression.
[Leukemia] |
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| The authors showed that Celf2 deficiency in hematopoietic system led to enhanced HSCs self-renewal and differentiation toward myeloid cells in mice.
[Oncogene] |
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| Using a single-cell omics approach combined with spatial proteomics and genetic fate-mapping models, researchers found that fetal liver macrophages clustered into distinct yolk sac-derived subpopulations and that long-term HSCs were interacting preferentially with one of the macrophage subpopulations.
[eLife] |
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| Using Kat6b germline deletion and overexpression in mice, scientists determined the role of KAT6B in the hematopoietic system.
[Stem Cell Reports] |
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| In a phenotypical screen of 56 AML patient samples and using a library of 10,000 compounds, investigators identified a hit with increased sensitivity toward SF3B1-mutated and adverse risk AMLs.
[Science Advances] |
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| The authors revealed that AKT3 behaved distinctly than AKT1M or AKT2 in both normal myeloid differentiation and AML.
[Scientific Reports] |
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| Scientists review the changes in the aging bone marrow (BM) niche and the emerging evidence supporting the concept that clonal hematopoiesis can progressively alter components of the local BM microenvironment.
[Leukemia] |
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| The authors comprehensively summarize the function of m6A modification in erythropoiesis and further generalize the mechanism of m6A modification regulating ineffective erythropoiesis and fetal hemoglobin expression.
[Clinical Genetics] |
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| Takeda announced that the Japanese Ministry of Health, Labour, and Welfare has approved the use of ADZYNMA for the treatment of cTTP for individuals 12 years of age and older.
[Takeda] |
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| | Cedars-Sinai – Los Angeles , California, United States |
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| | University of Virginia – Charlottesville , Virginia, United States |
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| | Universitätsklinikum Köln – Cologne, Germany |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | Francis Crick Institute – London, England, United Kingdom |
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Cancer Stem Cell News
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